Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690623 | 0.89 | RARG (0.41) | RARGRXRAPPARGL3MBTL1IKBKB | |
| SCHEMBL688542 | 0.85 | RARG (0.36) | RARGRXRAPPARGPDE3BPDE3A | |
| SCHEMBL13960086 | 0.84 | RARG (0.37) | RARGRXRAPPARGPDE3BPDE3A | |
| SCHEMBL1404705 | 0.80 | RARG (0.38) | RARGRXRAPPARGL3MBTL1IKBKB | |
| SCHEMBL13130524 | 0.79 | RARG (0.34) | RARGRXRAPPARGPDE3BPDE3A | |
| SCHEMBL690167 | 0.79 | MAPT (0.38) | RARGRXRAPPARGL3MBTL1IKBKB | |
| SCHEMBL5110866 | 0.78 | CYP2C19 (0.50) | RARGRXRAPPARGIKBKBHTT | |
| SCHEMBL688617 | 0.77 | HPGD (0.44) | L3MBTL1MAPTSMN1; SMN2HTTTSHR | |
| SCHEMBL690108 | 0.77 | ALOX5 (0.39) | RARGRXRAPPARGTP53MAPT | |
| SCHEMBL689665 | 0.76 | MAPT (0.41) | RARGRXRAPPARGL3MBTL1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |