Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690623 | 0.86 | RARG (0.41) | GAAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL690167 | 0.85 | MAPT (0.38) | ALDH1A1MAPTTP53SMN1; SMN2KDM4E | |
| SCHEMBL690830 | 0.82 | LMNA (0.42) | GAAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL689596 | 0.80 | CNR1 (0.45) | ALDH1A1 | |
| SCHEMBL1404705 | 0.77 | RARG (0.38) | GAAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL692947 | 0.77 | HTT (0.42) | GAAALDH1A1MAPTTP53SMN1; SMN2 | |
| SCHEMBL690317 | 0.77 | RARG (0.36) | ALDH1A1MAPTTP53SMN1; SMN2KDM4E | |
| SCHEMBL692574 | 0.74 | GSK3A (0.41) | ALDH1A1MAPTTP53SMN1; SMN2KDM4E | |
| SCHEMBL16106403 | 0.74 | GSK3A (0.43) | ALDH1A1MAPTTP53SMN1; SMN2KDM4E | |
| SCHEMBL689665 | 0.74 | MAPT (0.41) | ALDH1A1MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323980-B1 | 7-(PIPERAZINE-1-YMETHYL)-1H-INDOLE-2-CARBOXYLIC ACID (PHENYL)-AMIDE DERIVATIVES AND ALLIED COMPOUNDS AS P38 MAP KINASE INHIBITORS FOR THE TREATMENT OF RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INT (DE) | 2012-02-29 | — | — | EP | claimed |