Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.58 |
| ▸ | ACHE | P22303 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.58 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CDK1 | P06493 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16450984 | 0.84 | STING1 (0.67) | DYRK1AACHEKDM4EALDH1A1HPGD | |
| SCHEMBL18487741 | 0.81 | DYRK1A (0.55) | DYRK1AACHEKDM4EALDH1A1HPGD | |
| SCHEMBL2330779 | 0.77 | KDM4E (0.68) | DYRK1AACHEKDM4EALDH1A1HPGD | |
| SCHEMBL29533596 | 0.77 | KDM4E (0.68) | DYRK1AACHEKDM4EALDH1A1HPGD | |
| SCHEMBL7737505 | 0.76 | DYRK1A (0.60) | DYRK1AACHEKDM4EALDH1A1HPGD | |
| SCHEMBL689559 | 0.76 | KDM4E (0.55) | DYRK1AACHEKDM4EALDH1A1HPGD | |
| SCHEMBL5964419 | 0.75 | KIF11 (0.56) | KDM4EALDH1A1HPGDCYP1A2CYP3A4 | |
| SCHEMBL7250494 | 0.75 | KDM4E (0.55) | DYRK1AACHEKDM4EALDH1A1HPGD | |
| SCHEMBL30939881 | 0.75 | DYRK1A (0.74) | DYRK1AACHEKDM4EALDH1A1HPGD | |
| SCHEMBL16102894 | 0.75 | DYRK1A (0.74) | DYRK1AACHEKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200247751-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2020-08-06 | — | — | US | disclosed |
| US-10457639-B2 | Fluorescent regulators of RASSF1A expression and human cancer cell proliferation | GEORGETOWN UNIVERSITY (US) | 2019-10-29 | — | — | US | disclosed |
| US-10457639-B2 | Fluorescent regulators of RASSF1A expression and human cancer cell proliferation | GEORGETOWN UNIVERSITY (US) | 2019-10-29 | — | — | US | disclosed |
| US-20190077755-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2019-03-14 | — | — | US | disclosed |
| US-10173978-B2 | Small molecule androgen receptor inhibitors and methods of use thereof | GEORGETOWN UNIVERSITY (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180215712-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2018-08-02 | — | — | US | disclosed |
| EP-2484666-A1 | Fluorescent regulators of RASSF1A expression and human cancer cell proliferation | Georgetown University (US) | 2012-08-08 | — | — | EP | disclosed |
| EP-2323982-B1 | FLUORESCENT REGULATORS OF RASSF1A EXPRESSION AND HUMAN CANCER CELL PROLIFERATION | UNIV GEORGETOWN (US) | 2012-02-29 | — | — | EP | disclosed |
| EP-2323982-B1 | FLUORESCENT REGULATORS OF RASSF1A EXPRESSION AND HUMAN CANCER CELL PROLIFERATION | UNIV GEORGETOWN (US) | 2012-02-29 | — | — | EP | disclosed |
| US-20110152339-A1 | FLUORESCENT REGULATORS OF RASSF1A EXPRESSION AND HUMAN CANCER CELL PROLIFERATION | GEORGETOWN UNIVERSITY | 2011-06-23 | — | — | US | disclosed |
| US-20110152339-A1 | FLUORESCENT REGULATORS OF RASSF1A EXPRESSION AND HUMAN CANCER CELL PROLIFERATION | GEORGETOWN UNIVERSITY | 2011-06-23 | — | — | US | disclosed |
| US-20100130579-A1 | CANCER THERAPY | GEORGETOWN UNIVERSITY (US) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180215712-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | AR, KLK3, BRDT | DYRK1A 2487/4885ACHE 4683/4885KDM4E 1811/4885 |
| US-20190077755-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | AR, KLK3, BRDT | DYRK1A 2487/4885ACHE 4683/4885KDM4E 1811/4885 |
| US-20110152339-A1 | FLUORESCENT REGULATORS OF RASSF1A EXPRESSION AND HUMAN CANCER CELL PROLIFERATION | RASSF5, RASSF2, MKI67 | DYRK1A 2619/4885ACHE 4748/4885KDM4E 1073/4885 |
| US-20200247751-A1 | SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF | AR, KLK3, BRDT | DYRK1A 2487/4885ACHE 4683/4885KDM4E 1811/4885 |
| US-20100130579-A1 | CANCER THERAPY | RASSF5, RASSF2, DNMT1 | DYRK1A 4535/4885ACHE 4750/4885KDM4E 331/4885 |
| US-10173978-B2 | Small molecule androgen receptor inhibitors and methods of use thereof | AR, KLK3, BRDT | DYRK1A 2487/4885ACHE 4683/4885KDM4E 1811/4885 |
| US-10457639-B2 | Fluorescent regulators of RASSF1A expression and human cancer cell proliferation | RASSF5, RASSF2, MKI67 | DYRK1A 2619/4885ACHE 4748/4885KDM4E 1073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.