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Pemaglitazar

Pemaglitazar

SCHEMBL6903499

Cc1ccccc1SCCC(Oc1ccc(C(F)(F)F)cc1)C(=O)O.O=C(O)C(CCSc1cccc(Cl)c1)Oc1ccc(C(F)(F)F)cc1

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ PPARG P37231 12/20 0.45
▸ PPARA Q07869 12/20 0.45
▸ PTPN1 P18031 2/20 0.41
▸ SLC6A9 P48067 1/20 0.37
▸ PPARD Q03181 4/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pemaglitazar SCHEMBL6902218 0.91 PPARA (0.52) PPARGPPARAPTPN1SLC6A9PPARD
Pemaglitazar SCHEMBL6902223 0.91 PPARA (0.52) PPARGPPARAPTPN1SLC6A9PPARD
SCHEMBL3973311 0.91 PPARG (0.54) PPARGPPARAPTPN1
Pemaglitazar SCHEMBL29908544 0.89 PPARG (0.56) PPARGPPARAPTPN1SLC6A9
Pemaglitazar SCHEMBL3971139 0.89 PPARG (0.56) PPARGPPARAPTPN1SLC6A9
Pemaglitazar SCHEMBL3971148 0.89 PPARG (0.56) PPARGPPARAPTPN1SLC6A9
Pemaglitazar SCHEMBL3971735 0.89 PPARG (0.56) PPARGPPARAPTPN1SLC6A9
Pemaglitazar SCHEMBL6904072 0.87 PPARG (0.54) PPARGPPARAPTPN1SLC6A9
Pemaglitazar SCHEMBL6904388 0.85 PPARG (0.52) PPARGPPARAPTPN1SLC6A9
Pemaglitazar SCHEMBL6904078 0.85 PPARG (0.52) PPARGPPARAPTPN1SLC6A9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1412326-A1 BUTYRIC ACID DERIVATIVES MERCK PATENT GmbH (DE) 2004-04-28 — — EP disclosed
WO-2003011819-A1 BUTYRIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2003-02-13 — — WO disclosed