Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pemaglitazar. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.54 |
| ▸ | PPARA | Q07869 | 10/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pemaglitazar SCHEMBL3971139 | 0.98 | PPARG (0.56) | PPARGPPARAPTPN1SLC6A9NPC1 | |
| Pemaglitazar SCHEMBL3971148 | 0.98 | PPARG (0.56) | PPARGPPARAPTPN1SLC6A9NPC1 | |
| Pemaglitazar SCHEMBL29908544 | 0.98 | PPARG (0.56) | PPARGPPARAPTPN1SLC6A9NPC1 | |
| Pemaglitazar SCHEMBL3971735 | 0.98 | PPARG (0.56) | PPARGPPARAPTPN1SLC6A9NPC1 | |
| Pemaglitazar SCHEMBL6904388 | 0.94 | PPARG (0.52) | PPARGPPARAPTPN1SLC6A9NPC1 | |
| Pemaglitazar SCHEMBL6902223 | 0.94 | PPARA (0.52) | PPARGPPARAPTPN1SLC6A9NPC1 | |
| Pemaglitazar SCHEMBL6902218 | 0.94 | PPARA (0.52) | PPARGPPARAPTPN1SLC6A9NPC1 | |
| Pemaglitazar SCHEMBL6904078 | 0.94 | PPARG (0.52) | PPARGPPARAPTPN1SLC6A9NPC1 | |
| SCHEMBL11992998 | 0.87 | PPARG (0.58) | PPARGPPARAPTPN1SLC6A9 | |
| SCHEMBL11993063 | 0.87 | PPARG (0.46) | PPARGPPARAPTPN1SLC6A9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412326-A1 | BUTYRIC ACID DERIVATIVES | MERCK PATENT GmbH (DE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003011819-A1 | BUTYRIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2003-02-13 | — | — | WO | disclosed |