Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6898646 | 0.81 | ALDH1A1 (0.44) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| (S)-Temafloxacin SCHEMBL48096 | 0.73 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Temafloxacin SCHEMBL134294 | 0.73 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Temafloxacin SCHEMBL48095 | 0.73 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Temafloxacin SCHEMBL29414891 | 0.73 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Temafloxacin SCHEMBL20769825 | 0.73 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| (S)-Temafloxacin SCHEMBL9667109 | 0.73 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Temafloxacin SCHEMBL2637551 | 0.73 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Temafloxacin SCHEMBL134293 | 0.73 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| Temafloxacin SCHEMBL9667105 | 0.73 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDHSD17B10PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401829-A4 | NOVEL HETEROCYCLIC ANTIBACTERIAL COMPOUNDS | MICROBIOTIX INC (US) | 2004-10-27 | — | — | EP | disclosed |
| EP-1401829-A1 | NOVEL HETEROCYCLIC ANTIBACTERIAL COMPOUNDS | Microbiotix, Inc. (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002102792-A1 | NOVEL HETEROCYCLIC ANTIBACTERIAL COMPOUNDS | MICROBIOTIX, INC. (US) | 2002-12-27 | — | — | WO | disclosed |