Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6902508 | 0.92 | MEN1 (0.33) | HTR6CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL6904306 | 0.86 | CYP2E1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL6901373 | 0.85 | S1PR5 (0.32) | — | |
| Hydrochloric Acid SCHEMBL6901127 | 0.84 | CA12 (0.35) | CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL6902770 | 0.82 | CA12 (0.36) | CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL6903694 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL6903947 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL6903511 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL2521566 | 0.81 | SLC6A4 (0.33) | CA12CA1CA2CA9SLC6A4 | |
| Hydrochloric Acid SCHEMBL6903873 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |