Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 8/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 7/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6903490 | 0.92 | S1PR5 (0.33) | S1PR5S1PR4 | |
| Hydrochloric Acid SCHEMBL6904306 | 0.88 | CYP2E1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL6903694 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL6903947 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL6903511 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL6902174 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL6904413 | 0.85 | HTR6 (0.33) | — | |
| Hydrochloric Acid SCHEMBL6898085 | 0.85 | BACE1 (0.35) | S1PR5S1PR4CCNCCDK8 | |
| Hydrochloric Acid SCHEMBL6899121 | 0.84 | ADORA2A (0.33) | S1PR5S1PR4 | |
| Hydrochloric Acid SCHEMBL6903873 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |