Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diphenhydramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.81 |
| ▸ | LMNA | P02545 | 5/20 | 0.84 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.84 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.81 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.81 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.81 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.81 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.81 |
| ▸ | DRD3 | P35462 | 3/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.81 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.81 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.81 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.81 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.81 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenhydramine SCHEMBL10487818 | 0.92 | LMNA (1.00) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL17071 | 0.92 | LMNA (1.00) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL27912373 | 0.90 | SLC6A2 (0.93) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL12543374 | 0.90 | SLC6A2 (1.00) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL4064 | 0.90 | SLC6A2 (1.00) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL25219551 | 0.88 | SLC6A2 (0.96) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL9565209 | 0.88 | SLC6A2 (0.96) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL11795332 | 0.88 | SLC6A2 (0.96) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL29205078 | 0.88 | SLC6A2 (0.96) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 | |
| Diphenhydramine SCHEMBL28210970 | 0.88 | SLC6A2 (0.96) | LMNAPMP22KDM4EMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227821-A4 | THERAPEUTIC COMPOSITIONS AND METHODS OF USE THEREOF | HODOSH MILTON (US) | 2004-09-22 | — | — | EP | disclosed |
| EP-1227821-A1 | THERAPEUTIC COMPOSITIONS AND METHODS OF USE THEREOF | HODOSH, Milton (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001034165-A1 | THERAPEUTIC COMPOSITIONS AND METHODS OF USE THEREOF | HODOSH MILTON (US) | 2001-05-17 | — | — | WO | disclosed |
| US-6099868-A | APPLYING POTASSIUM COMPOUND AND ETHYLENEDIAMINETETRAACETIC ACID TO ANESTHETIZE TOOTH | HODOSH MILTON (US) | 2000-08-08 | — | — | US | disclosed |