Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6899133 | 0.84 | ALDH1A1 (0.36) | ALDH1A1RAB9ANPC1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL6904019 | 0.84 | ALDH1A1 (0.36) | ALDH1A1RAB9ANPC1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL6899196 | 0.84 | ALDH1A1 (0.36) | ALDH1A1RAB9ANPC1KMT2AMAPT | |
| SCHEMBL7121713 | 0.84 | ALDH1A1 (0.36) | ALDH1A1RAB9ANPC1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL6902969 | 0.76 | BRD4 (0.33) | RAB9ANPC1S1PR1LMNATP53 | |
| Hydrochloric Acid SCHEMBL6902678 | 0.76 | KDM4E (0.30) | ALDH1A1KDM4EHPGDHSD17B10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6902702 | 0.75 | TRPV1 (0.39) | ALDH1A1RAB9ANPC1KMT2AMAPT | |
| SCHEMBL7122880 | 0.73 | TRPV1 (0.39) | ALDH1A1RAB9ANPC1KMT2AMAPT | |
| SCHEMBL6900002 | 0.73 | TRPV1 (0.39) | ALDH1A1RAB9ANPC1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL6903459 | 0.73 | TRPV1 (0.39) | ALDH1A1RAB9ANPC1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1033371-B1 | Transition metal compound, catalyst system, process for the preparation thereof and its use for the polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6458982-B1 | CATALYST SYSTEM COMPRISING AT LEAST ONE METALLOCENE AND AT LEAST ONE COCATALYST. ON SUPPORT. | TARGOR GMBH (DE) | 2002-10-01 | — | — | US | disclosed |