Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GRK6 | P43250 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6903 | 1.00 | KAT2B (0.43) | KAT2BMAPTALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL6263 | 0.92 | KAT2B (0.44) | KAT2BMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6261 | 0.92 | KAT2B (0.44) | KAT2BMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11909741 | 0.89 | KAT2B (0.45) | KAT2BMAPTALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL11909744 | 0.89 | KAT2B (0.45) | KAT2BMAPTALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL6121 | 0.88 | NPY5R (0.42) | MAPTALDH1A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL6123 | 0.88 | NPY5R (0.42) | MAPTALDH1A1CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL5748 | 0.87 | ALDH1A1 (0.48) | MAPTALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL5746 | 0.87 | ALDH1A1 (0.48) | MAPTALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL5913 | 0.85 | KMT2A (0.44) | KAT2BMAPTALDH1A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |