SCHEMBL6905045

SCHEMBL6905045

Bc1ccc2nc(Cl)c(C=O)cc2c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.57
CYP3A4 P08684 1/20 0.57
CYP2D6 P10635 1/20 0.57
CYP2C19 P33261 1/20 0.57
ALDH1A1 P00352 2/20 0.54
KDM4E B2RXH2 2/20 0.46
MAPT P10636 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
MEN1 O00255 1/20 0.46
MPI P34949 1/20 0.46
KMT2A Q03164 1/20 0.46
TDP1 Q9NUW8 1/20 0.37
LMNA P02545 1/20 0.35
HTT P42858 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
GSK3B P49841 1/20 0.35
KDR P35968 8/20 0.35
EGFR P00533 1/20 0.35
ALOX5 P09917 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30129703 0.81 CYP1A2 (0.61) CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1
SCHEMBL6304224 0.81 CYP1A2 (0.61) CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1
SCHEMBL12672175 0.79 CYP1A2 (0.57) CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1
SCHEMBL11971423 0.79 CYP1A2 (0.57) CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1
SCHEMBL8672 0.79 CYP1A2 (0.57) CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1
SCHEMBL15941609 0.79 CYP1A2 (0.57) CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1
SCHEMBL1880623 0.79 ALDH1A1 (0.78) CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1
SCHEMBL372264 0.78 ALDH1A1 (0.62) CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1
Water SCHEMBL27927704 0.76 ALDH1A1 (0.60) CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1
SCHEMBL6074932 0.76 CYP1A2 (0.58) CYP1A2CYP3A4CYP2D6CYP2C19ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011063272-A1 AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE AMGEN INC. (US) 2011-05-26 WO disclosed