Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 12/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216535 | 0.90 | CCR2 (0.59) | CCR2LMNAMAPTGAAHTT | |
| SCHEMBL5220337 | 0.82 | CCR2 (0.58) | CCR2LMNAMAPTGAAHTT | |
| SCHEMBL6905139 | 0.82 | CCR2 (0.58) | CCR2LMNAMAPTGAAHTT | |
| SCHEMBL5213947 | 0.81 | CCR2 (0.77) | CCR2LMNAMAPTALDH1A1CYP1A2 | |
| SCHEMBL5213680 | 0.78 | CCR2 (0.65) | CCR2LMNAMAPTGAAHTT | |
| SCHEMBL8688955 | 0.77 | CCR2 (0.59) | CCR2LMNAMAPTGAAHTT | |
| SCHEMBL5214927 | 0.77 | CCR2 (0.59) | CCR2LMNAMAPTGAAHTT | |
| SCHEMBL2206316 | 0.77 | KMT2A (0.56) | GAAHTTALDH1A1HPGD | |
| SCHEMBL6780153 | 0.77 | ABCB11 (0.54) | CCR2LMNAMAPTGAAHTT | |
| SCHEMBL5214863 | 0.76 | CCR2 (0.76) | CCR2LMNAMAPTGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6833387-B1 | 3-substituted indoles; inhibition of monocyte chemoattractant protein-1 and/or RANTES induced chemotaxis; inflammatory diseases | ASTRAZENECA AB (SE) | 2004-12-21 | — | — | US | disclosed |