Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6905358 | 1.00 | ALDH1A1 (0.51) | ALDH1A1HPGDPOLBPSEN1PSEN2 | |
| SCHEMBL21676274 | 0.85 | VHL (0.50) | ALDH1A1HPGDPOLBPSEN1PSEN2 | |
| SCHEMBL1356508 | 0.81 | ALDH1A1 (0.54) | ALDH1A1HPGDPOLBGAATP53 | |
| SCHEMBL1356510 | 0.81 | ALDH1A1 (0.54) | ALDH1A1HPGDPOLBGAATP53 | |
| SCHEMBL11627001 | 0.81 | ALDH1A1 (0.45) | ALDH1A1HPGDPOLBNPSR1PLA2G1B | |
| SCHEMBL13411549 | 0.76 | ALDH1A1 (0.49) | ALDH1A1HPGDPOLBGAAHSD17B10 | |
| SCHEMBL2177216 | 0.75 | POLB (0.63) | ALDH1A1HPGDPOLBKMT2AMAPT | |
| SCHEMBL8035990 | 0.75 | POLB (0.63) | ALDH1A1HPGDPOLBKMT2AMAPT | |
| SCHEMBL2177223 | 0.75 | POLB (0.63) | ALDH1A1HPGDPOLBKMT2AMAPT | |
| SCHEMBL8809022 | 0.74 | ALDH1A1 (0.50) | ALDH1A1HPGDPOLBKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6683075-B1 | FUSED NITROGENHETEROCYCLIC AMIDES; ALZHEIMER'S DISEASE | ATHENA NEUROSCIENCES, INC. | 2004-01-27 | — | — | US | disclosed |