Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7059610 | 0.83 | PTGS2 (0.64) | PTGS2PTGS1GABRA2GABRB2 | |
| SCHEMBL5594726 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL213892 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL5594653 | 0.78 | PTGS2 (0.78) | PTGS2PTGS1 | |
| SCHEMBL5593885 | 0.78 | PTGS2 (0.78) | PTGS2PTGS1 | |
| SCHEMBL8488021 | 0.76 | PTGS1 (0.45) | PTGS2PTGS1GABRA2GABRB2ALDH1A3 | |
| SCHEMBL82549 | 0.75 | PTGS1 (0.62) | PTGS2PTGS1GABRA2GABRB2ALDH1A1 | |
| SCHEMBL21113586 | 0.75 | PTGS2 (0.63) | PTGS2PTGS1GABRA2GABRB2CNR1 | |
| SCHEMBL5698682 | 0.74 | PTGS2 (0.90) | PTGS2PTGS1 | |
| SCHEMBL3243606 | 0.74 | PTGS2 (0.90) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1443942-A1 | PHARMACEUTICAL COMPOSITION FOR USE FOR THE TREATMENT OF MALIGNANCIES COMPRISING IN COMBINATION A BISPHOSPHONATES, A COX-2 INHIBITOR AND A TAXOL | Novartis AG (CH) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003035081-A1 | PHARMACEUTICAL COMPOSITION FOR USE FOR THE TREATMENT OF MALIGNANCIES COMPRISING IN COMBINATION A BISPHOSPHONATES, A COX-2 INHIBITOR AND A TAXOL | NOVARTIS AG (CH) | 2003-05-01 | — | — | WO | disclosed |