Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12176971 | 0.82 | ASIC3 (0.45) | ASIC3MAPTALDH1A1TDP1KDM4E | |
| SCHEMBL690517 | 0.79 | MAPK1 (0.36) | EGFR | |
| SCHEMBL16102991 | 0.70 | HSP90AA1 (0.42) | ASIC3MAPTALDH1A1KDM4ECYP2D6 | |
| SCHEMBL1518829 | 0.69 | IRAK4 (0.44) | MAPTKDM4EL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL17032805 | 0.68 | ALDH1A1 (0.46) | MAPTALDH1A1TDP1KDM4ECYP1A2 | |
| SCHEMBL1518926 | 0.66 | KHK (0.39) | MAPTALDH1A1TDP1KDM4ECYP1A2 | |
| SCHEMBL27907258 | 0.66 | EGFR (0.44) | ASIC3MAPTALDH1A1EGFRCSF1R | |
| SCHEMBL23351082 | 0.65 | MAPT (0.41) | MAPTALDH1A1TDP1KDM4ECYP1A2 | |
| SCHEMBL26028769 | 0.65 | ALDH1A1 (0.45) | MAPTALDH1A1TDP1KDM4ECYP1A2 | |
| SCHEMBL21075886 | 0.64 | ALDH1A1 (0.48) | MAPTALDH1A1TDP1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421538-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | Avila Therapeutics, Inc. (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010123870-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2010-10-28 | — | — | WO | disclosed |