Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.82 |
| ▸ | TP53 | P04637 | 1/20 | 0.82 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.82 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.82 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 2/20 | 0.45 |
| ▸ | GABRD | O14764 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL28199472 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL11284804 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL554796 | 1.00 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL2223150 | 0.91 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL2223143 | 0.91 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL9261130 | 0.91 | TSHR (0.82) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL6875 | 0.91 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL615 | 0.91 | — | — | |
| Fumaric Acid SCHEMBL2046433 | 0.91 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL20487516 | 0.91 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE50049-E1 | Compositions and methods for treating psoriasis | SYTHEON LTD. (US) | 2024-07-23 | — | — | US | disclosed |
| US-20220168255-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DIMETHYL FUMARATE FOR ADMINISTRATION AT A LOW DAILY DOSE | BIOGEN SWISS MFG GMBH (CH) | 2022-06-02 | — | — | US | disclosed |
| US-20210290582-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DIMETHYL FUMARATE FOR ADMINISTRATION AT A LOW DAILY DOSE | BIOGEN SWISS MFG GMBH (CH) | 2021-09-23 | — | — | US | disclosed |
| EP-3273951-B1 | COMPOSITIONS AND METHODS FOR TREATING PSORIASIS | SYMBIONYX PHARMACEUTICALS INC (US) | 2020-07-29 | — | — | EP | disclosed |
| EP-3517102-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DIMETHYL FUMARATE FOR ADMINISTRATION AT A LOW DAILY DOSE | FWP IP APS (DK) | 2019-07-31 | — | — | EP | disclosed |
| US-20190201369-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DIMETHYL FUMARATE FOR ADMINISTRATION AT A LOW DAILY DOSE | BIOGEN SWISS MANUFACTURING GMBH (CH) | 2019-07-04 | — | — | US | disclosed |
| EP-3492072-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DIMETHYL FUMARATE FOR ADMINISTRATION AT A LOW DAILY DOSE | FWP IP APS (DK) | 2019-06-05 | — | — | EP | disclosed |
| US-20190125711-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DIMETHYL FUMARATE FOR ADMINISTRATION AT A LOW DAILY DOSE | BIOGEN SWISS MANUFACTURING GMBH (CH) | 2019-05-02 | — | — | US | disclosed |
| US-20180338946-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DIMETHYL FUMARATE FOR ADMINISTRATION AT A LOW DAILY DOSE | BIOGEN SWISS MANUFACTURING GMBH (CH) | 2018-11-29 | — | — | US | disclosed |
| US-20180256530-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DIMETHYL FUMARATE FOR ADMINISTRATION AT A LOW DAILY DOSE | BIOGEN SWISS MANUFACTURING GMBH (CH) | 2018-09-13 | — | — | US | disclosed |
| EP-3038606-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DIMETHYL FUMARATE FOR ADMINISTRATION AT A LOW DAILY DOSE | Forward Pharma A/S (DK) | 2016-07-06 | — | — | EP | disclosed |
| EP-3038605-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DIMETHYL FUMARATE FOR ADMINISTRATION AT A LOW DAILY DOSE | Forward Pharma A/S (DK) | 2016-07-06 | — | — | EP | disclosed |
| US-20150247133-A1 | METHODS AND TOOLS FOR IDENTIFICATION OF RSK/MSK KINASE INHIBITORS | AARHUS UNIVERSITET (DK) | 2015-09-03 | — | — | US | disclosed |
| EP-2900815-A1 | METHODS AND TOOLS FOR IDENTIFICATION OF RSK/MSK KINASE INHIBITORS | Aarhus Universitet (DK) | 2015-08-05 | — | — | EP | disclosed |
| WO-2015028472-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DIMETHYL FUMARATE FOR ADMINISTRATION AT A LOW DAILY DOSE | FORWARD PHARMA A/S (DK) | 2015-03-05 | — | — | WO | disclosed |
| WO-2015028473-A1 | PHARMACEUTICAL COMPOSITION CONTAINING DIMETHYL FUMARATE FOR ADMINISTRATION AT A LOW DAILY DOSE | FORWARD PHARMA A/S (DK) | 2015-03-05 | — | — | WO | disclosed |
| US-6806308-B2 | Method for protecting paint on an article, a composition useful therefor, and a method for making the composition | CHEMICO SYSTEMS, INC. | 2004-10-19 | — | — | US | disclosed |
| US-20020076487-A1 | Method for protecting paint on an article, a composition useful therefor, and a method for making the composition | ZAJAC BOHDAN (US) | 2002-06-20 | — | — | US | disclosed |
| US-6391961-B1 | Method for protecting paint on article, composition useful therefor, and method for making composition | PRODUCT SOL, L.L.C. | 2002-05-21 | — | — | US | disclosed |
| WO-1998055535-A1 | METHODS FOR PROTECTING PAINT ON AN ARTICLE, COMPOSITION USEFUL THEREFOR, AND METHOD FOR MAKING THE COMPOSITION | PRODUCT SOL, LLC. (US) | 1998-12-10 | — | — | WO | disclosed |