Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 1.00 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 1.00 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.53 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.47 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL650322 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL2046433 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL623596 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL3998225 | 1.00 | — | — | |
| Maleic Acid SCHEMBL613 | 1.00 | — | — | |
| Maleic Acid SCHEMBL20487516 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL2046432 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL2046430 | 1.00 | TSHR (1.00) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL615 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL1331192 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2323 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024096708-A1 | NOVEL CRYSTALLINE FORM OF A PYRIMIDINE COMPOUND AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND METHODS OF USE THEREOF | HANMI PHARM. CO., LTD. (KR) | 2024-05-10 | — | — | WO | claimed |
| WO-2024018394-A1 | A PROCESS FOR THE PREPARATION OF CRYSTALLINE FORM A OF N, N'-BIS(2-AMINOETHYL)-1,2-ETHANEDIAMINE TETRAHYDROCHLORIDE | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD (IN) | 2024-01-25 | — | — | WO | claimed |
| US-20240000935-A1 | ANTIGEN SPECIFIC T CELLS AND METHODS OF MAKING AND USING SAME | GENEIUS BIOTECHNOLOGY, INC. (US) | 2024-01-04 | — | — | US | claimed |
| WO-2024003797-A1 | CRYSTALLINE SALTS OF LISDEXAMFETAMINE | IND-SWIFT LABORATORIES LIMITED (IN) | 2024-01-04 | — | — | WO | claimed |
| EP-4251177-A2 | ANTIGEN SPECIFIC T CELLS AND METHODS OF MAKING AND USING SAME | Geneius Biotechnology, Inc. (US) | 2023-10-04 | — | — | EP | claimed |
| WO-2023143486-A1 | SALT, CRYSTALLINE FORM, SOLVATE AND HYDRATE OF COMPOUND | 深圳众格生物科技有限公司 | 2023-08-03 | — | — | WO | claimed |
| CN-115677675-A | Salt of 6-oxaspiro [4,5] decane compound, preparation method and application | 成都苑东生物制药股份有限公司 | 2023-02-03 | — | — | CN | claimed |
| EP-2437684-B1 | ANTERIOR SEGMENT DRUG DELIVERY | FORSIGHT VISION5 INC (US) | 2022-06-15 | — | — | EP | claimed |
| WO-2022115641-A2 | ANTIGEN SPECIFIC T CELLS AND METHODS OF MAKING AND USING SAME | GENEIUS BIOTECHNOLOGY, INC. (US) | 2022-06-02 | — | — | WO | claimed |
| US-20220117989-A1 | COMPOSITIONS AND METHODS FOR INDUCING OR SUPPLEMENTING SOCS3 TO ABROGATE TUMOR GROWTH AND PROLIFERATIVE RETINOPATHY | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-04-21 | — | — | US | claimed |
| US-4840991-A | ADDITION POLYMERS FOR COATINGS | DESOTO, INC. (US) | 1989-06-20 | — | — | US | claimed |
| US-4839403-A | DISPERSION OF EPOXY PHOSPHATE SALT, CURING AGENT AND HYDROXY-CONTAINING ACRYLIC POLYMER | DESOTO, INC. (US) | 1989-06-13 | — | — | US | claimed |
| EP-0268913-A2 | Aqueous dispersions of partially cross-linked emulsion copolymers | DeSoto, Inc. (US) | 1988-06-01 | — | — | EP | claimed |
| EP-0111588-B1 | PHYSICALLY-AMELIORATED STYRENE POLYMER/THERMOPLASTIC ELASTOMER POLYBLENDS | THE DOW CHEMICAL COMPANY (US) | 1987-09-09 | — | — | EP | claimed |
| EP-0092479-B1 | N,N'-SUBSTITUTED POLYMETHYLENE DIAMINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR (FR) | 1986-01-29 | — | — | EP | claimed |
| EP-0090733-B1 | DISUBSTITUTED POLYMETHYLENE IMINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR (FR) | 1985-10-30 | — | — | EP | claimed |
| US-4514398-A | Disubstituted polymethylene imines | ADIR (FR) | 1985-04-30 | — | — | US | claimed |
| US-4514399-A | N-N'substituted polymethylene diamines | ADIR (FR) | 1985-04-30 | — | — | US | claimed |
| EP-0092479-A1 | N,N'-substituted polymethylene diamines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1983-10-26 | — | — | EP | claimed |
| EP-0090733-A1 | Disubstituted polymethylene imines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1983-10-05 | — | — | EP | claimed |