Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.62 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | VEGFA | P15692 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | PDE5A | O76074 | 1/20 | 0.62 |
| ▸ | TNF | P01375 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | PDE1A | P54750 | 1/20 | 0.62 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6052153 | 0.88 | MTNR1A (0.57) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3544677 | 0.80 | MTNR1A (0.51) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3546305 | 0.79 | MTNR1A (0.55) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL18117796 | 0.78 | MTNR1A (0.66) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL19559337 | 0.78 | MTNR1A (0.66) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL10701867 | 0.77 | CA2 (0.46) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL18117756 | 0.77 | MTNR1A (0.64) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL19559348 | 0.77 | MTNR1A (0.64) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL19559399 | 0.77 | MTNR1A (0.64) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL18117787 | 0.77 | MTNR1A (0.64) | PDE4APDE4BPDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758233-B1 | PDE IV INHIBITORS FOR TREATING MULTIPLE SCLEROSIS | SCHERING AG (DE) | 2003-12-03 | — | — | EP | claimed |
| EP-0758233-A1 | PDE IV INHIBITORS FOR TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-02-19 | — | — | EP | claimed |
| WO-1995028926-A1 | PDE IV INHIBITORS FOR TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-11-02 | — | — | WO | claimed |
| EP-1380291-A1 | PDE IV inhibitors for treating multiple sclerosis | Schering Aktiengesellschaft (DE) | 2004-01-14 | — | — | EP | disclosed |
| EP-0758233-B1 | PDE IV INHIBITORS FOR TREATING MULTIPLE SCLEROSIS | SCHERING AG (DE) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002051502-A1 | COMBINED INHIBITION OF PHOSPHODIESTERASE-4 (PDE-4) AND PHOSPHODIESTERASE-3 (PDE-3) AS A THERAPY FOR TH1-MEDIATED AUTOIMMUNE DISEASES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2002-07-04 | — | — | WO | disclosed |
| US-6060501-A | ADMINISTERING SYNERGISTIC MIXTURE OF A PHOSPHODIESTERASE INHIBITOR AND AN INTERFERON | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-09 | — | — | US | disclosed |
| EP-0758233-A1 | PDE IV INHIBITORS FOR TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-02-19 | — | — | EP | disclosed |
| WO-1995028926-A1 | PDE IV INHIBITORS FOR TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-11-02 | — | — | WO | disclosed |