Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 5/20 | 0.66 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.66 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.66 |
| ▸ | NNMT | P40261 | 3/20 | 0.66 |
| ▸ | NSD2 | O96028 | 3/20 | 0.66 |
| ▸ | SETD7 | Q8WTS6 | 3/20 | 0.66 |
| ▸ | TRDMT1 | O14717 | 2/20 | 0.66 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.66 |
| ▸ | INMT | O95050 | 2/20 | 0.66 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.66 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.66 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.66 |
| ▸ | METTL14 | Q9HCE5 | 2/20 | 0.66 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.66 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.66 |
| ▸ | PNMT | P11086 | 1/20 | 0.66 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.66 |
| ▸ | HNMT | P50135 | 1/20 | 0.66 |
| ▸ | WDR5 | P61964 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5055541 | 0.85 | AHCY (0.76) | DOT1LPNMTDNMT1KMT2APRMT7 | |
| SCHEMBL6935387 | 0.83 | AHCY (0.78) | DOT1LPNMTDNMT1KMT2ADNMT3B | |
| SCHEMBL1490897 | 0.83 | AHCY (0.76) | DOT1LPNMTDNMT1KMT2ADNMT3B | |
| SCHEMBL6907707 | 0.83 | DOT1L (0.70) | DOT1LCARM1EHMT2NNMTNSD2 | |
| SCHEMBL17540920 | 0.82 | AHCY (0.74) | DOT1LCARM1EHMT2NNMTNSD2 | |
| SCHEMBL8943568 | 0.82 | AHCY (0.74) | DOT1LPNMTDNMT1KMT2ADNMT3B | |
| SCHEMBL8943736 | 0.82 | AHCY (0.74) | DOT1LPNMTDNMT1KMT2ADNMT3B | |
| SCHEMBL17551937 | 0.82 | AHCY (0.74) | DOT1LCARM1EHMT2NNMTNSD2 | |
| SCHEMBL8943648 | 0.82 | AHCY (0.74) | DOT1LPNMTDNMT1KMT2ADNMT3B | |
| SCHEMBL19434083 | 0.82 | AHCY (0.74) | DOT1LCARM1EHMT2NNMTNSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040043959-A1 | Combination therapies for treating methylthioadenosine phosphorylase deficient cells | AGOURON PHARMACEUTICALS INC. | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043959-A1 | Combination therapies for treating methylthioadenosine phosphorylase deficient cells | APRT, MTAP, TYMP | DOT1L 1250/4885CARM1 998/4885EHMT2 465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.