Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 5/20 | 0.76 |
| ▸ | NADK | O95544 | 1/20 | 0.76 |
| ▸ | SRM | P19623 | 4/20 | 0.76 |
| ▸ | SMS | P52788 | 2/20 | 0.76 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.72 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.72 |
| ▸ | PNMT | P11086 | 1/20 | 0.72 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.72 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.70 |
| ▸ | DPP4 | P27487 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.69 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.69 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.69 |
| ▸ | GAPDH | P04406 | 1/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.69 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935387 | 0.88 | AHCY (0.78) | AHCYNADKSRMDOT1LDNMT3B | |
| SCHEMBL3488878 | 0.88 | AHCY (0.78) | AHCYNADKSRMSMSDOT1L | |
| SCHEMBL1490897 | 0.87 | AHCY (0.76) | AHCYNADKSRMSMSDOT1L | |
| SCHEMBL30249742 | 0.86 | SRM (1.00) | AHCYNADKSRMSMSDOT1L | |
| SCHEMBL8943648 | 0.86 | AHCY (0.74) | AHCYNADKSRMDOT1LDNMT3B | |
| SCHEMBL8943736 | 0.86 | AHCY (0.74) | AHCYNADKSRMSMSDOT1L | |
| SCHEMBL8943568 | 0.86 | AHCY (0.74) | AHCYNADKSRMSMSDOT1L | |
| SCHEMBL21243035 | 0.86 | DOT1L (0.84) | AHCYNADKDOT1LDNMT3BPNMT | |
| SCHEMBL6907682 | 0.85 | DOT1L (0.66) | AHCYNADKSRMSMSDOT1L | |
| Methylthioadenosine SCHEMBL11954365 | 0.84 | AHCY (0.83) | AHCYNADKDOT1LDNMT3BPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080132525-A1 | isoforms DNMT1 and DNMT3b2; for example: 2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid | METHYLGENE INC. (CA) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132525-A1 | isoforms DNMT1 and DNMT3b2; for example: 2-amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenethylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid | DNMT3B, DNMT1, DNMT3L | AHCY 278/4885NADK 3499/4885SRM 1185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.