Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 9/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14118248 | 1.00 | CTSS (0.46) | CTSSCTSLCTSKHDAC4HDAC1 | |
| SCHEMBL6907732 | 0.91 | CTSS (0.44) | CTSSCTSLCTSKHDAC4HDAC1 | |
| SCHEMBL16408513 | 0.84 | CTSL (0.43) | CTSSCTSLCTSKHDAC4HDAC1 | |
| SCHEMBL1962816 | 0.83 | CTSS (0.42) | CTSSCTSLCTSKCTSBPPARA | |
| SCHEMBL2341125 | 0.83 | CTSS (0.42) | CTSSCTSLCTSKCTSBPPARA | |
| SCHEMBL1965485 | 0.83 | CTSS (0.42) | CTSSCTSLCTSKCTSBPPARA | |
| SCHEMBL6908367 | 0.83 | CTSS (0.42) | CTSSCTSLCTSKCTSBPPARA | |
| SCHEMBL15086624 | 0.83 | CTSS (0.45) | CTSSCTSLCTSKHDAC4HDAC1 | |
| SCHEMBL14118177 | 0.81 | CTSS (0.37) | CTSSCTSLCTSKPPARAACE | |
| SCHEMBL15866396 | 0.81 | CTSS (0.44) | CTSSCTSLCTSKHDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815809-B2 | Cysteine protease inhibitors | MEDIVIR UK LTD (GB) | 2014-08-26 | — | — | US | disclosed |
| EP-2509956-B1 | CYSTEINE PROTEASE INHIBITORS | MEDIVIR UK LTD (GB) | 2014-07-23 | — | — | EP | disclosed |
| WO-2011070539-A1 | CYSTEINE PROTEASE INHIBITORS | MEDIVIR UK LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |