Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 6/20 | 0.32 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.32 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.32 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.32 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CCL2 | P13500 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704957 | 0.98 | HTR2A (0.35) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| Fluoride SCHEMBL7640655 | 0.96 | HTR2A (0.34) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| Hydrochloric Acid SCHEMBL8163839 | 0.96 | HTR2A (0.34) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| SCHEMBL8754923 | 0.96 | HTR2A (0.34) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| Hydrochloric Acid SCHEMBL271905 | 0.96 | HTR2A (0.34) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| Hydrochloric Acid SCHEMBL7766826 | 0.94 | HTR2A (0.33) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| Methyl Alcohol SCHEMBL7766797 | 0.94 | HTR2A (0.33) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| Dimethylamine SCHEMBL8357752 | 0.93 | KDM4E (0.37) | HTR2AHTR6SIGMAR1KDM4EBRD4 | |
| Toluene SCHEMBL7807743 | 0.90 | LMNA (0.37) | HTR2AHTR6SIGMAR1KDM4ELMNA | |
| SCHEMBL6555216 | 0.85 | TSHR (0.42) | HTR2ASIGMAR1KDM4ELMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783022-B2 | ETHYLENIC POLYMER COMPOSITION | MITSUI CHEMICALS INC (JP) | 2016-01-20 | — | — | EP | disclosed |
| EP-0783022-B1 | ETHYLENIC POLYMER COMPOSITION | MITSUI CHEMICALS INC (JP) | 2004-09-22 | — | — | EP | disclosed |
| EP-0891382-B1 | ALPHA-OLEFIN-CYCLOOLEFIN COPOLYMERS AND PROCESS FOR THEIR PRODUCTION | TEIJIN LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| US-6476153-B2 | INCLUDES A STEP OF DISTILLING UNREACTED DICYCLOPENTADIENE OR HYDROGENATED PRODUCT THEREOF, TETRAHYDRODICYCLOPENTADIENE FROM A MIXTURE OF THE COPOLYMER OR ITS HYDROGENATED PRODUCT IN THE PRESENCE OF A HIGH BOILING HYDROCARBON SOLVENT | TEIJIN LIMITED (JP) | 2002-11-05 | — | — | US | disclosed |
| US-6388032-B1 | SEPARATION BY FILTRATION | TEIJIN LIMITED (JP) | 2002-05-14 | — | — | US | disclosed |
| US-20010009950-A1 | Process for producing hydrogenated alpha-olefin- dicyclopentadiene copolymer, method for molding the same and optical material | HASHIDZUME KIYONARI (JP) | 2001-07-26 | — | — | US | disclosed |
| EP-0678530-B1 | Process for production of cyclic olefin copolymers and copolymers produced by said process | MITSUI CHEMICALS INC (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-6232407-B1 | MELT PROCESSABILITY | TEIJIN LIMITED (JP) | 2001-05-15 | — | — | US | disclosed |
| EP-0719803-B1 | Process for the production of cycloolefin random copolymer | MITSUI CHEMICALS INC (JP) | 2001-03-21 | — | — | EP | disclosed |
| US-6191243-B1 | ADDITION COPOLYMER HAVING HIGH DEGREE OF ALTERNATING ACYCLIC OLEFIN-DICYCLOPENTADIENE UNITS; OPTICAL RECORDING MEDIA SUBSTRATES | TEIJIN LIMITED (JP) | 2001-02-20 | — | — | US | disclosed |
| WO-1998033830-A1 | ALPHA-OLEFIN-CYCLOOLEFIN COPOLYMERS AND PROCESS FOR THEIR PRODUCTION | TEIJIN LIMITED (JP) | 1998-08-06 | — | — | WO | disclosed |
| US-5650471-A | COPOLYMERIZING AN ALPHA-OLEFIN AND A CYCLOOLEFIN IN THE PRESENCE OF A CATALYST FORMED FROM A TRANSITION METAL COMPOUND AND AN ORGANIC ALUMINUM COMPOUND | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-22 | — | — | US | disclosed |
| EP-0783022-A1 | ETHYLENIC POLYMER COMPOSITION | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-09 | — | — | EP | disclosed |
| EP-0768320-A1 | Catalyst component and catalyst | NIPPON OIL CO. LTD. (JP) | 1997-04-16 | — | — | EP | disclosed |
| US-5559199-A | MOLECULAR WEIGHT CONTROL | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0729983-A2 | Process for the production of cycloolefin random copolymer | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1996-09-04 | — | — | EP | disclosed |
| EP-0719803-A2 | Process for the production of cycloolefin random copolymer | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1996-07-03 | — | — | EP | disclosed |
| EP-0678530-A1 | Process for production of cyclic olefin copolymers and copolymers produced by said process | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-25 | — | — | EP | disclosed |
| US-5334664-A | Graft polymerization an unsaturated cyclic copolymer of propylene, bicycloheptene or tetracyclododecene with vinyl, vinylidene, unsaturated dicarboxylic acids or esters monomers | MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) | 1994-08-02 | — | — | US | disclosed |
| EP-0570126-A1 | Method for producing graft-modified copolymers | MITSUBISHI CHEMICAL CORPORATION (JP) | 1993-11-18 | — | — | EP | disclosed |