Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 16/20 | 0.55 |
| ▸ | ABCC8 | Q09428 | 16/20 | 0.55 |
| ▸ | KCNJ11 | Q14654 | 16/20 | 0.55 |
| ▸ | KCNJ8 | Q15842 | 16/20 | 0.55 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6911320 | 0.93 | ABCC9 (0.62) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL6912871 | 0.84 | ABCC9 (0.50) | ABCC9ABCC8KCNJ11KCNJ8VCAM1 | |
| SCHEMBL6910817 | 0.81 | ABCC9 (0.70) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL7250504 | 0.80 | ABCC9 (0.57) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL6912853 | 0.72 | ABCC9 (0.56) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL7267078 | 0.70 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL7267067 | 0.70 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8KMT2A | |
| SCHEMBL7643822 | 0.69 | ABCC9 (0.87) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL11860028 | 0.69 | KMT2A (0.65) | KMT2AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL7266650 | 0.68 | HIF1A (0.60) | ABCC9ABCC8KCNJ11KCNJ8KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040097-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2004-04-14 | — | — | EP | disclosed |