Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 7/20 | 0.56 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | TYK2 | P29597 | 3/20 | 0.53 |
| ▸ | JAK1 | P23458 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8268504 | 0.83 | ITGB1 (0.56) | ITGB1ITGA4KMT2AJAK2TYK2 | |
| SCHEMBL8258392 | 0.83 | RAB9A (0.56) | ITGB1ITGA4KMT2APOLBMEN1 | |
| SCHEMBL678659 | 0.83 | KMT2A (0.67) | ITGB1ITGA4KMT2APOLBMEN1 | |
| SCHEMBL8269199 | 0.83 | TYK2 (0.60) | ITGB1ITGA4POLBLMNAJAK2 | |
| SCHEMBL3514566 | 0.83 | TYK2 (0.75) | ITGB1ITGA4KMT2AMEN1JAK2 | |
| SCHEMBL4063160 | 0.81 | ITGB1 (0.64) | ITGB1ITGA4JAK2TYK2JAK1 | |
| SCHEMBL4063435 | 0.81 | ITGB1 (0.55) | ITGB1ITGA4KMT2AJAK2TYK2 | |
| SCHEMBL15091418 | 0.80 | KMT2A (0.62) | KMT2APOLBMEN1LMNAPKM | |
| SCHEMBL6514115 | 0.76 | ITGB1 (0.65) | ITGB1ITGA4NR1H4 | |
| SCHEMBL6514112 | 0.76 | ITGB1 (0.58) | ITGB1ITGA4JAK2TYK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040102478-A1 | Substituted n-arylsulfonyl-proline derivatives as potent cell adhesion inhibitors | MERCK & CO., INC. | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102478-A1 | Substituted n-arylsulfonyl-proline derivatives as potent cell adhesion inhibitors | VCAM1, CD4, ICAM1 | ITGB1 28/4885ITGA4 4/4885KMT2A 1121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.