Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.78 |
| ▸ | MAPK11 | Q15759 | 15/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 14/20 | 0.67 |
| ▸ | GCGR | P47871 | 14/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 14/20 | 0.67 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.67 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.67 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.67 |
| ▸ | FRK | P42685 | 4/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.67 |
| ▸ | GSK3B | P49841 | 4/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.67 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.67 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.67 |
| ▸ | PRKACA | P17612 | 3/20 | 0.60 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551864 | 0.88 | ALOX5 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL15075603 | 0.82 | MAPK11 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL19868925 | 0.82 | MAPK11 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL5622957 | 0.81 | ALOX5 (0.87) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL2650684 | 0.78 | MAPK11 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL4552013 | 0.77 | ALOX5 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL67376 | 0.77 | ALOX5 (0.65) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL4552316 | 0.77 | MAPK14 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL2650702 | 0.77 | MAPK11 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL9195042 | 0.77 | MAPK14 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | BRAF, ARAF, KRAS | ALOX5 4390/4885MAPK11 362/4885MAPK14 484/4885 |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | BRAF, RAF1, HRAS | ALOX5 3656/4885MAPK11 186/4885MAPK14 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.