Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORD | Q00796 | 3/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MMP14 | P50281 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | CASP6 | P55212 | 2/20 | 0.33 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6365200 | 0.76 | NPC1 (0.35) | CRHBPCRHR2KEAP1NFE2L2MEN1 | |
| SCHEMBL6676223 | 0.73 | CRHBP (0.40) | CRHBPCRHR2KEAP1NFE2L2TDP1 | |
| SCHEMBL5457433 | 0.73 | CRHBP (0.37) | CRHBPCRHR2KEAP1NFE2L2MAPT | |
| SCHEMBL6676368 | 0.70 | CRHBP (0.49) | CRHBPCRHR2KEAP1NFE2L2TDP1 | |
| SCHEMBL6676030 | 0.70 | PDE5A (0.41) | CRHBPCRHR2KEAP1NFE2L2MEN1 | |
| SCHEMBL5066814 | 0.69 | TDP1 (0.38) | CRHBPCRHR2KEAP1NFE2L2TDP1 | |
| SCHEMBL29864580 | 0.69 | TDP1 (0.38) | CRHBPCRHR2KEAP1NFE2L2TDP1 | |
| SCHEMBL30361763 | 0.69 | PDPK1 (0.42) | CRHBPCRHR2KEAP1NFE2L2TDP1 | |
| SCHEMBL1651160 | 0.69 | PDPK1 (0.42) | CRHBPCRHR2KEAP1NFE2L2TDP1 | |
| SCHEMBL6673705 | 0.69 | CRHBP (0.34) | CRHBPCRHR2KEAP1NFE2L2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972517-B1 | Use of 1,2,4-benzotriazine oxides for the preparation of a medicament for the treatment of tumors | UNIV LELAND STANFORD JUNIOR (US) | 2004-07-07 | — | — | EP | disclosed |
| US-6277835-B1 | ADMINISTERING SYNERGISTIC DOSAGE OF A 1,2,4-BENZOTRIAZINE OXIDE COMPOUND CYTOLYTIC AGENT EFFECTIVE AGAINST HYPOXIC TUMOR CELLS AND AN ANTITUMOR AGENT EFFECTIVE AGAINST OXYGENATED TUMOR CELLS | THE BOARD OF TRUSTEES OF LELAND STANFORD JUNIOR UNIVERSITY | 2001-08-21 | — | — | US | disclosed |
| US-6121263-A | Method of tumor treatment | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0649658-B1 | Use of 1,2,4-benzotriazine oxides for the manufacture of a medicament for the treatment of tumors | UNIV LELAND STANFORD JUNIOR (US) | 2000-06-14 | — | — | EP | disclosed |
| EP-0972517-A2 | Use of 1,2,4-benzotriazine oxides for the preparation of a medicament for the treatment of tumours | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2000-01-19 | — | — | EP | disclosed |
| US-5670502-A | Method of tumor treatment | THE BOARD OF TRUSTEES OF LELAND STANFORD JR. UNIV. (US) | 1997-09-23 | — | — | US | disclosed |
| US-5484612-A | Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0649658-A1 | Method of tumor treatment | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 1995-04-26 | — | — | EP | disclosed |