Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 10/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6909564 | 0.90 | PDE8B (1.00) | PDE8BALDH1A1MEN1KMT2A | |
| SCHEMBL6911420 | 0.81 | PDE8B (0.83) | PDE8B | |
| SCHEMBL6911029 | 0.80 | PDE8B (0.81) | PDE8B | |
| SCHEMBL6910848 | 0.78 | PDE8B (0.77) | PDE8BALDH1A1KDM4ESMN1; SMN2DRD4 | |
| SCHEMBL6910849 | 0.78 | PDE8B (0.77) | PDE8BALDH1A1KDM4ESMN1; SMN2DRD4 | |
| SCHEMBL6910428 | 0.77 | PDE8B (1.00) | PDE8B | |
| SCHEMBL6911364 | 0.74 | PDE8B (0.71) | PDE8BDRD4 | |
| SCHEMBL1759315 | 0.72 | PDE8B (0.54) | PDE8BALDH1A1MEN1KMT2AGAA | |
| SCHEMBL6910604 | 0.72 | PDE8B (1.00) | PDE8B | |
| SCHEMBL6909200 | 0.70 | PDE8B (0.77) | PDE8B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058478-A1 | SUBSTITUTED TRIAZOLOPYRIMIDINES AS PDE8 INHIBITORS | PFIZER INC. (US) | 2011-05-19 | — | — | WO | disclosed |