Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 19/20 | 0.71 |
| ▸ | PDE8A | O60658 | 3/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6910855 | 0.90 | PDE8B (0.68) | PDE8BPDE8ADRD4 | |
| SCHEMBL6911420 | 0.87 | PDE8B (0.83) | PDE8BPDE8A | |
| SCHEMBL6911029 | 0.85 | PDE8B (0.81) | PDE8BPDE8A | |
| SCHEMBL6909564 | 0.83 | PDE8B (1.00) | PDE8BPDE8A | |
| SCHEMBL6911266 | 0.80 | PDE8B (0.72) | PDE8BPDE8ADRD4 | |
| SCHEMBL6910351 | 0.79 | PDE8B (0.77) | PDE8BPDE8A | |
| SCHEMBL6910428 | 0.78 | PDE8B (1.00) | PDE8BPDE8A | |
| SCHEMBL6910356 | 0.78 | PDE8B (0.71) | PDE8BPDE8A | |
| SCHEMBL6910604 | 0.76 | PDE8B (1.00) | PDE8BPDE8A | |
| SCHEMBL6910056 | 0.74 | PDE8B (0.81) | PDE8BDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058478-A1 | SUBSTITUTED TRIAZOLOPYRIMIDINES AS PDE8 INHIBITORS | PFIZER INC. (US) | 2011-05-19 | — | — | WO | disclosed |