Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.40 |
| ▸ | DRD2 | P14416 | 7/20 | 0.40 |
| ▸ | HTR1A | P08908 | 6/20 | 0.40 |
| ▸ | HTR7 | P34969 | 6/20 | 0.40 |
| ▸ | HTR6 | P50406 | 6/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6796026 | 0.92 | HTR1D (0.48) | HTR1DMAPTLMNAOPRM1OPRK1 | |
| SCHEMBL7220152 | 0.86 | OPRM1 (0.51) | HTR1DLMNAOPRM1OPRK1SLC6A4 | |
| SCHEMBL7219902 | 0.86 | HTR1D (0.52) | HTR1DMAPTLMNAOPRM1OPRK1 | |
| SCHEMBL6796662 | 0.86 | OPRM1 (0.50) | OPRM1OPRK1SLC6A4DRD2HTR1A | |
| SCHEMBL7219879 | 0.85 | HTR1D (0.54) | HTR1DMAPTLMNASLC6A4DRD2 | |
| SCHEMBL7219472 | 0.85 | HTR1D (0.48) | HTR1DLMNAOPRM1OPRK1SLC6A4 | |
| SCHEMBL7213738 | 0.84 | HTR1D (0.51) | HTR1DSLC6A4DRD2HTR1AHTR7 | |
| SCHEMBL7216019 | 0.83 | HTR1D (0.51) | HTR1DSLC6A4DRD2HTR1AHTR7 | |
| Oxalic Acid SCHEMBL7214633 | 0.83 | HTR1D (0.52) | HTR1DMAPTLMNAOPRM1OPRK1 | |
| SCHEMBL6802859 | 0.82 | HTR1D (0.49) | HTR1DLMNAOPRM1OPRK1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6767907-B2 | FOR THERAPY OF PSYCHIC AND NEUROLOGIC DISORDERS | H. LUNDBECK A/S (DK) | 2004-07-27 | — | — | US | disclosed |
| US-6743808-B1 | PSYCHOLOGICAL AND NEUROLOGIC DISORDERS; CENTRAL SEROTONERGIC 5-HT1A AND 5-HT2A RECEPTOR ANTAGONISTS | H. LUNDBECK A/S (DK) | 2004-06-01 | — | — | US | disclosed |
| US-6218394-B1 | FOR THERAPY OF SCHIZOPHRENIA, OTHER PSYCHOSES, ANXIETY DISORDERS, SUCH AS GENERALISED ANXIETY DISORDER, PANIC DISORDER | H. LUNDBECK A/S (DK) | 2001-04-17 | — | — | US | disclosed |
| EP-0765311-B1 | 4-ARYL-1-(INDANMETHYL, DIHYDROBENZOFURANMETHYL OR DIHYDROBENZOTHIOPHENEMETHYL)PIPERIDINES, TETRAHYDROPYRIDINES OR PIPERAZINES | LUNDBECK & CO AS H (DK) | 2000-10-04 | — | — | EP | disclosed |