Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 7/20 | 0.43 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 3/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 8/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 6/20 | 0.42 |
| ▸ | HTR7 | P34969 | 6/20 | 0.42 |
| ▸ | HTR6 | P50406 | 6/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7219879 | 0.98 | HTR1D (0.54) | HTR1DMTNR1ADRD2SLC6A4ADRA1D | |
| Oxalic Acid SCHEMBL7220017 | 0.96 | HTR1D (0.49) | HTR1DMTNR1ADRD2SLC6A4HTR1A | |
| Oxalic Acid SCHEMBL7219944 | 0.95 | HTR1D (0.49) | HTR1DMTNR1ADRD2SLC6A4HTR1A | |
| SCHEMBL7213738 | 0.93 | HTR1D (0.51) | HTR1DMTNR1ADRD2SLC6A4HTR1A | |
| SCHEMBL7216019 | 0.93 | HTR1D (0.51) | HTR1DMTNR1ADRD2SLC6A4HTR1A | |
| SCHEMBL6796026 | 0.90 | HTR1D (0.48) | HTR1DMTNR1ADRD2SLC6A4HTR1A | |
| SCHEMBL6811593 | 0.85 | HTR1D (0.53) | HTR1DDRD2SLC6A4ADRA1DHTR1B | |
| SCHEMBL7219902 | 0.84 | HTR1D (0.52) | HTR1DDRD2SLC6A4ADRA1DHTR1B | |
| SCHEMBL6796662 | 0.84 | OPRM1 (0.50) | DRD2SLC6A4HTR1AHTR7HTR6 | |
| Oxalic Acid SCHEMBL7572885 | 0.83 | HTR1D (0.53) | HTR1DDRD2SLC6A4ADRA1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6552044-B2 | Dopamine receptors | H. LUNDBECK A/S (DK) | 2003-04-22 | — | — | US | disclosed |
| EP-0946542-B1 | INDANE OR DIHYDROINDOLE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2002-10-09 | — | — | EP | disclosed |
| US-20010021777-A1 | Indane or dihydroindole derivatives | H. LUNDBECK A/S (DK) | 2001-09-13 | — | — | US | disclosed |
| US-20010020095-A1 | Indane or dihydroindole derivatives | H. LUNDBECK A/S (DK) | 2001-09-06 | — | — | US | disclosed |
| US-6262087-B1 | HAVE HIGH AFFINITY FOR D4 RECEPTORS; USEFUL IN THE TREATMENT OF CERTAIN PSYCHIATRIC AND NEUROLOGIC DISORDERS, INCLUDING PSYCHOSIS, DEPRESSION AND ANXIETY. | H. LUNDBECK A/S (DK) | 2001-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020095-A1 | Indane or dihydroindole derivatives | HTR4, GPR4, GPR174 | SLC6A4 40/4885OPRM1 34/4885HTR1D 4/4885 |
| US-20010021777-A1 | Indane or dihydroindole derivatives | HTR4, GPR4, GPR174 | SLC6A4 40/4885OPRM1 34/4885HTR1D 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.