Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13156563 | 0.80 | TLR8 (0.51) | TLR8S1PR4S1PR1S1PR5HTR2A | |
| SCHEMBL18805360 | 0.80 | TLR8 (0.51) | TLR8S1PR4S1PR1S1PR5HTR2A | |
| SCHEMBL19478673 | 0.79 | PSMB5 (0.52) | TLR8S1PR4S1PR1S1PR5HTR2A | |
| SCHEMBL5398097 | 0.78 | TLR8 (0.53) | TLR8DHFR | |
| SCHEMBL10479144 | 0.78 | TLR8 (0.53) | TLR8DHFR | |
| SCHEMBL8608786 | 0.76 | TLR8 (0.52) | TLR8DHFR | |
| SCHEMBL23130637 | 0.74 | PSMB5 (0.57) | TLR8RAB9AHPGDSMN1; SMN2SKP2 | |
| SCHEMBL3397263 | 0.74 | TLR8 (0.47) | TLR8S1PR4S1PR1S1PR5KDM4E | |
| SCHEMBL5998084 | 0.73 | TLR8 (0.46) | TLR8S1PR4S1PR1S1PR5HTR2A | |
| SCHEMBL6347222 | 0.72 | ESR1 (0.47) | TLR8HTR2AKDM4ERAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0972517-B1 | Use of 1,2,4-benzotriazine oxides for the preparation of a medicament for the treatment of tumors | UNIV LELAND STANFORD JUNIOR (US) | 2004-07-07 | — | — | EP | disclosed |
| US-6277835-B1 | ADMINISTERING SYNERGISTIC DOSAGE OF A 1,2,4-BENZOTRIAZINE OXIDE COMPOUND CYTOLYTIC AGENT EFFECTIVE AGAINST HYPOXIC TUMOR CELLS AND AN ANTITUMOR AGENT EFFECTIVE AGAINST OXYGENATED TUMOR CELLS | THE BOARD OF TRUSTEES OF LELAND STANFORD JUNIOR UNIVERSITY | 2001-08-21 | — | — | US | disclosed |
| US-6121263-A | Method of tumor treatment | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0649658-B1 | Use of 1,2,4-benzotriazine oxides for the manufacture of a medicament for the treatment of tumors | UNIV LELAND STANFORD JUNIOR (US) | 2000-06-14 | — | — | EP | disclosed |
| EP-0972517-A2 | Use of 1,2,4-benzotriazine oxides for the preparation of a medicament for the treatment of tumours | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2000-01-19 | — | — | EP | disclosed |
| US-5670502-A | Method of tumor treatment | THE BOARD OF TRUSTEES OF LELAND STANFORD JR. UNIV. (US) | 1997-09-23 | — | — | US | disclosed |
| US-5484612-A | Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0649658-A1 | Method of tumor treatment | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 1995-04-26 | — | — | EP | disclosed |