Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.40 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28781815 | 0.86 | CYP4F2 (0.45) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL3033628 | 0.85 | BCL2 (0.50) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL8580572 | 0.85 | PRSS1 (0.46) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL6671053 | 0.83 | PRSS1 (0.52) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL12669377 | 0.82 | KMT2A (0.46) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL10389972 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1HPGDRAB9ACES2 | |
| SCHEMBL2643704 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL2643707 | 0.81 | LOXL2 (0.62) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL13819738 | 0.81 | KAT6A (0.50) | SMN1; SMN2NPC1HPGDRAB9AMAPT | |
| SCHEMBL14544564 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1HPGDRAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108929263-A | Aryl amide Kv2.1 inhibitor and preparation method thereof, pharmaceutical composition and purposes | 中国医学科学院药物研究所 | 2018-12-04 | — | — | CN | disclosed |
| CN-107567442-A | Inhibitors of hepatitis C virus polymerase | 共晶制药公司 | 2018-01-09 | — | — | CN | disclosed |
| EP-1112998-B1 | AMINE DERIVATIVES | POLA CHEM IND INC (JP) | 2004-12-08 | — | — | EP | disclosed |
| US-6586633-B1 | Antifungal agents | POLA CHEMICAL INDUSTRIES, INC. (JP) | 2003-07-01 | — | — | US | disclosed |
| EP-1112998-A1 | AMINE DERIVATIVES | POLA CHEMICAL INDUSTRIES, INC. (JP) | 2001-07-04 | — | — | EP | disclosed |
| US-4265898-A | ANTICOAGULANTS | BAYER AKTIENGESELLSCHAFT (DE) | 1981-05-05 | — | — | US | disclosed |