Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.74 |
| ▸ | RET | P07949 | 5/20 | 0.69 |
| ▸ | EGFR | P00533 | 9/20 | 0.66 |
| ▸ | KDR | P35968 | 6/20 | 0.66 |
| ▸ | SRC | P12931 | 4/20 | 0.66 |
| ▸ | BRAF | P15056 | 1/20 | 0.65 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.65 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | ABL1 | P00519 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | FBP1 | P09467 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.65 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.65 |
| ▸ | FLT1 | P17948 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL12003639 | 0.99 | LRRK2 (0.72) | LRRK2RETEGFRKDRSRC | |
| SCHEMBL25688818 | 0.84 | LRRK2 (0.80) | LRRK2RETEGFRKDRSRC | |
| SCHEMBL1804035 | 0.84 | TNNI3K (0.80) | LRRK2RETEGFRKDRSRC | |
| SCHEMBL16087034 | 0.83 | LRRK2 (0.63) | LRRK2RETEGFRKDRSRC | |
| SCHEMBL6911408 | 0.82 | TNNI3K (0.67) | EGFRSRCBRAFTNNI3K | |
| SCHEMBL6912603 | 0.81 | TNNI3K (0.57) | LRRK2EGFRBRAFTNNI3K | |
| Hydrochloric Acid SCHEMBL12003695 | 0.81 | TNNI3K (0.66) | EGFRBRAFTNNI3K | |
| SCHEMBL25679222 | 0.81 | LRRK2 (0.81) | LRRK2RETEGFRKDRSRC | |
| SCHEMBL6912147 | 0.81 | EGFR (0.66) | LRRK2RETEGFRKDRSRC | |
| SCHEMBL14982743 | 0.80 | LRRK2 (0.84) | LRRK2RETEGFRKDRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859571-B2 | Quinazoline compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-14 | — | — | US | claimed |
| EP-2501233-B1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2014-09-24 | — | — | EP | claimed |
| US-20120220588-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-08-30 | — | — | US | claimed |
| US-8859571-B2 | Quinazoline compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859571-B2 | Quinazoline compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-14 | — | — | US | disclosed |
| EP-2501233-B1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2014-09-24 | — | — | EP | disclosed |
| EP-2501233-B1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20120220588-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-08-30 | — | — | US | disclosed |
| US-20120220588-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-08-30 | — | — | US | disclosed |
| WO-2011056740-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220588-A1 | QUINAZOLINE COMPOUNDS | NQO2, PRMT7, QDPR | LRRK2 220/4885RET 1565/4885EGFR 3336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.