Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.66 |
| ▸ | KDR | P35968 | 5/20 | 0.66 |
| ▸ | RET | P07949 | 3/20 | 0.66 |
| ▸ | FBP1 | P09467 | 2/20 | 0.66 |
| ▸ | CLK1 | P49759 | 2/20 | 0.66 |
| ▸ | KIF5B | P33176 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.66 |
| ▸ | INSR | P06213 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | FLT4 | P35916 | 1/20 | 0.66 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.66 |
| ▸ | TEK | Q02763 | 1/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.66 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.66 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 4/20 | 0.61 |
| ▸ | FLT1 | P17948 | 1/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL12003566 | 0.99 | EGFR (0.65) | EGFRKDRRETFBP1CLK1 | |
| SCHEMBL6911482 | 0.85 | KDR (0.60) | EGFRKDRRETKIF5BFLT4 | |
| Hydrochloric Acid SCHEMBL12003797 | 0.84 | EGFR (0.60) | EGFRKDRRETKIF5BFLT4 | |
| SCHEMBL6911042 | 0.81 | LRRK2 (0.74) | EGFRKDRRETFBP1KIF5B | |
| SCHEMBL6912484 | 0.81 | BRAF (0.71) | EGFRKDRRETKIF5BFLT4 | |
| SCHEMBL2099106 | 0.80 | EGFR (1.00) | EGFRKDRFBP1CLK1AURKA | |
| SCHEMBL30505605 | 0.80 | EGFR (1.00) | EGFRKDRFBP1CLK1AURKA | |
| SCHEMBL6792594 | 0.80 | EGFR (0.74) | EGFRKDRRETFBP1CLK1 | |
| Hydrochloric Acid SCHEMBL12003561 | 0.80 | BRAF (0.69) | EGFRKDRRETKIF5BFLT4 | |
| Hydrochloric Acid SCHEMBL12003639 | 0.80 | LRRK2 (0.72) | EGFRKDRRETFBP1KIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859571-B2 | Quinazoline compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-14 | — | — | US | claimed |
| EP-2501233-B1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2014-09-24 | — | — | EP | claimed |
| US-20120220588-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-08-30 | — | — | US | claimed |
| US-8859571-B2 | Quinazoline compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859571-B2 | Quinazoline compounds | GLAXOSMITHKLINE LLC (US) | 2014-10-14 | — | — | US | disclosed |
| EP-2501233-B1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2014-09-24 | — | — | EP | disclosed |
| EP-2501233-B1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2014-09-24 | — | — | EP | disclosed |
| US-20120220588-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-08-30 | — | — | US | disclosed |
| US-20120220588-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC | 2012-08-30 | — | — | US | disclosed |
| WO-2011056740-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220588-A1 | QUINAZOLINE COMPOUNDS | NQO2, PRMT7, QDPR | EGFR 3336/4885KDR 2042/4885RET 1565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.