Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 20/20 | 0.63 |
| ▸ | DRD2 | P14416 | 19/20 | 0.63 |
| ▸ | HTR2C | P28335 | 3/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.63 |
| ▸ | HRH1 | P35367 | 3/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.63 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.63 |
| ▸ | DRD1 | P21728 | 2/20 | 0.63 |
| ▸ | DRD4 | P21917 | 2/20 | 0.63 |
| ▸ | DRD5 | P21918 | 2/20 | 0.63 |
| ▸ | HTR1D | P28221 | 2/20 | 0.63 |
| ▸ | HTR1B | P28222 | 2/20 | 0.63 |
| ▸ | HTR7 | P34969 | 2/20 | 0.63 |
| ▸ | DRD3 | P35462 | 2/20 | 0.63 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.63 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 12/20 | 0.52 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6912078 | 0.87 | HTR2A (0.48) | HTR2ADRD2HTR2CADRA1AHRH1 | |
| SCHEMBL13394316 | 0.86 | DRD2 (0.62) | HTR2ADRD2HTR2CADRA1AHRH1 | |
| SCHEMBL21074575 | 0.80 | HTR2A (0.43) | HTR2ADRD2HTR2CADRA1AHRH1 | |
| SCHEMBL805329 | 0.77 | HTR2A (0.40) | HTR2ADRD2HTR2CADRA1AHRH1 | |
| Paliperidone SCHEMBL436689 | 0.77 | DRD2 (1.00) | HTR2ADRD2HTR2CADRA1AHRH1 | |
| Paliperidone SCHEMBL67205 | 0.77 | DRD2 (1.00) | HTR2ADRD2HTR2CADRA1AHRH1 | |
| Paliperidone SCHEMBL11899798 | 0.77 | DRD2 (1.00) | HTR2ADRD2HTR2CADRA1AHRH1 | |
| Paliperidone SCHEMBL20572022 | 0.77 | DRD2 (1.00) | HTR2ADRD2HTR2CADRA1AHRH1 | |
| Paliperidone SCHEMBL29409219 | 0.77 | DRD2 (1.00) | HTR2ADRD2HTR2CADRA1AHRH1 | |
| Paliperidone SCHEMBL29377584 | 0.77 | DRD2 (1.00) | HTR2ADRD2HTR2CADRA1AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011030224-A2 | PALIPERIDONE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF SUBSTANTIALLY FREE OF IMPURITIES | ACTAVIS GROUP PTC EHF (IS) | 2011-03-17 | — | — | WO | disclosed |
| WO-2009118655-A2 | HIGHLY PURE PALIPERIDONE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF SUBSTANTIALLY FREE OF KETO IMPURITY | ACTAVIS GROUP PTC EHF (IS) | 2009-10-01 | — | — | WO | disclosed |
| WO-2009056990-A2 | PALIPERIDONE POLYMORPHS | ACTAVIS GROUP PTC EHF (US) | 2009-05-07 | — | — | WO | disclosed |
| WO-2008087557-A2 | AN IMPROVED PROCESS FOR PREPARATION OF 9-HYDROXY-3-(2-CHLOROETHYL)- 2-METHYL-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE HYDROCHLORIDE | ACTAVIS GROUP PTC EHF (US) | 2008-07-24 | — | — | WO | disclosed |