Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691606 | 0.89 | ALDH1A1 (0.47) | ALDH1A1MEN1CASP1KMT2ACYP1A2 | |
| SCHEMBL1452051 | 0.78 | CYP2A6 (0.42) | MEN1KMT2ACYP1A2CYP2C19HTT | |
| SCHEMBL9901980 | 0.77 | BDKRB2 (0.35) | CYP1A2NPC1RAB9A | |
| SCHEMBL9318593 | 0.76 | ALDH1A1 (0.58) | ALDH1A1MEN1CASP1CASP7KMT2A | |
| SCHEMBL12957491 | 0.74 | CYP3A4 (0.60) | ALDH1A1MEN1CASP1CASP7KMT2A | |
| SCHEMBL6115165 | 0.74 | ALDH1A1 (0.51) | ALDH1A1MEN1CASP1CASP7KMT2A | |
| SCHEMBL6114945 | 0.73 | ALDH1A1 (0.50) | ALDH1A1MEN1CASP1CASP7KMT2A | |
| Quinoline SCHEMBL28162427 | 0.72 | ALDH1A1 (0.71) | ALDH1A1MEN1CASP1CASP7KMT2A | |
| Quinoline SCHEMBL28025239 | 0.72 | ALDH1A1 (0.71) | ALDH1A1MEN1CASP1CASP7KMT2A | |
| SCHEMBL6114869 | 0.72 | TLR8 (0.49) | ALDH1A1MEN1CASP1CASP7KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190659-A1 | ANGIOGENESIS INHIBITORS | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2012-07-26 | — | — | US | disclosed |
| EP-2421882-A2 | ANGIOGENESIS INHIBITORS | President and Fellows of Harvard College (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010123545-A2 | ANGIOGENESIS INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-10-28 | — | — | WO | disclosed |
| US-5141931-A | 5-Quinolinylpyridinones, cardiotonic compositions and methods | STERLING WINTHROP INC. (US) | 1992-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190659-A1 | ANGIOGENESIS INHIBITORS | VEGFA, KDR, FLT1 | ALDH1A1 614/4885MEN1 3581/4885CASP1 2314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.