Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 9/20 | 1.00 |
| ▸ | HTR1B | P28222 | 9/20 | 1.00 |
| ▸ | HTR5A | P47898 | 4/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29406058 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR5AHTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL6977751 | 0.99 | HTR1D (0.98) | HTR1DHTR1BHTR5ASLC6A4MPO | |
| SCHEMBL6973429 | 0.84 | HTR1D (0.73) | HTR1DHTR1B | |
| SCHEMBL6969966 | 0.81 | HTR1D (0.67) | HTR1DHTR1BHTR5AHTR1ASLC6A4 | |
| SCHEMBL6964618 | 0.80 | HTR1D (0.66) | HTR1DHTR1BHTR1A | |
| SCHEMBL7006151 | 0.77 | HTR1D (0.63) | HTR1DHTR1BHTR5AHTR1ASLC6A4 | |
| SCHEMBL7006155 | 0.77 | HTR1D (0.63) | HTR1DHTR1BHTR5AHTR1ASLC6A4 | |
| SCHEMBL6963490 | 0.77 | HTR1D (0.62) | HTR1DHTR1BHTR5AHTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL6977748 | 0.76 | HTR1D (0.61) | HTR1DHTR1BHTR5AHTR1ASLC6A4 | |
| SCHEMBL7008663 | 0.76 | HTR1D (0.61) | HTR1DHTR1BHTR5AHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239878-B1 | FORMULATIONS OF ADENOSINE A1 AGONISTS AND 5HT1 AGONISTS | GLAXO GROUP LTD (GB) | 2004-02-25 | — | — | EP | claimed |
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | claimed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | claimed |
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | disclosed |