Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1438646 | 0.99 | PNMT (0.46) | PNMTIDO1TDO2HTR2AHTR2C | |
| SCHEMBL2105356 | 0.80 | PNMT (0.43) | PNMTIDO1TDO2ACP3DAO | |
| SCHEMBL9679731 | 0.78 | PNMT (0.59) | PNMTIDO1TDO2HTR2AHTR2C | |
| SCHEMBL17842112 | 0.77 | PNMT (0.49) | PNMTIDO1TDO2HTR2AHTR2C | |
| SCHEMBL4535035 | 0.76 | DPP4 (0.38) | — | |
| SCHEMBL3836311 | 0.73 | IDO1 (0.60) | PNMTIDO1TDO2HTR2AHTR2C | |
| SCHEMBL8113192 | 0.72 | PNMT (0.37) | PNMTIDO1TDO2DAO | |
| Hydrochloric Acid SCHEMBL11876965 | 0.72 | IDO1 (0.63) | PNMTIDO1TDO2HTR2AHTR2C | |
| SCHEMBL4386660 | 0.71 | PNMT (0.43) | PNMTIDO1TDO2HTR2AHTR2C | |
| SCHEMBL24017114 | 0.70 | PNMT (0.59) | PNMTIDO1TDO2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120208852-A1 | Heterocyclic-substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-08-16 | — | — | US | disclosed |
| US-20120208852-A1 | Heterocyclic-substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-08-16 | — | — | US | disclosed |
| WO-2011023703-A1 | HETEROCYCLIC-SUBSTITUTED 2-ACETAMIDO-5-ARYL-1,2,4-TRIAZOLONES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208852-A1 | Heterocyclic-substituted 2-acetamido-5-aryl-1,2,4-triazolones and use thereof | AADAC, NAT1, TNNI3 | PNMT 1343/4885IDO1 1929/4885TDO2 2061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.