Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 10/20 | 0.39 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6917143 | 0.93 | DRD3 (0.33) | MMP13SLC22A8DRD3KCNH2 | |
| SCHEMBL6704758 | 0.90 | GRM5 (0.44) | MMP13SLC22A8GRM5GRIN1DRD3 | |
| SCHEMBL6706809 | 0.87 | MMP13 (0.42) | MMP13SLC22A8GRM5DRD3KCNH2 | |
| SCHEMBL6706842 | 0.86 | MMP13 (0.48) | MMP13SLC22A8GRM5 | |
| SCHEMBL5697101 | 0.86 | MMP13 (0.41) | MMP13SLC22A8GRM5 | |
| SCHEMBL6706890 | 0.85 | MMP13 (0.55) | MMP13SLC22A8GRM5FFAR1FFAR4 | |
| SCHEMBL6706100 | 0.85 | MMP13 (0.42) | MMP13SLC22A8GRM5 | |
| SCHEMBL6706967 | 0.83 | MMP13 (0.38) | MMP13SLC22A8GRM5FFAR1FFAR4 | |
| SCHEMBL6919220 | 0.82 | MMP13 (0.40) | MMP13GRM5 | |
| SCHEMBL6704965 | 0.79 | MMP13 (0.42) | MMP13SLC22A8GRM5FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014869-A2 | 5,6-FUSED 3,4-DIHYDROPYRIMIDINE-2-ONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | claimed |