Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | QPCT | Q16769 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6706938 | 0.87 | MMP13 (0.41) | MMP13GPR84CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL6915307 | 0.82 | MMP13 (0.39) | MMP13GRM5 | |
| SCHEMBL6917143 | 0.82 | DRD3 (0.33) | MMP13 | |
| SCHEMBL6706896 | 0.72 | CYP3A4 (0.36) | MMP13 | |
| SCHEMBL6704758 | 0.71 | GRM5 (0.44) | MMP13GRM5 | |
| SCHEMBL6706809 | 0.69 | MMP13 (0.42) | MMP13GRM5 | |
| SCHEMBL6706842 | 0.68 | MMP13 (0.48) | MMP13CYP11B1CYP11B2FNTAFNTB | |
| SCHEMBL6706048 | 0.67 | MMP13 (0.37) | MMP13 | |
| SCHEMBL6706100 | 0.67 | MMP13 (0.42) | MMP13FNTAFNTBGRM5 | |
| SCHEMBL6706890 | 0.67 | MMP13 (0.55) | MMP13GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014869-A2 | 5,6-FUSED 3,4-DIHYDROPYRIMIDINE-2-ONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | claimed |
| WO-2004014869-A2 | 5,6-FUSED 3,4-DIHYDROPYRIMIDINE-2-ONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |