Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691341 | 0.79 | POLB (0.38) | — | |
| SCHEMBL17175797 | 0.68 | PIK3CD (0.38) | ADORA2AADORA2B | |
| SCHEMBL11691084 | 0.67 | ADORA2A (0.45) | ADORA2AADORA2BNOS3NOS2 | |
| SCHEMBL38663355 | 0.67 | — | — | |
| SCHEMBL5223298 | 0.67 | — | — | |
| SCHEMBL690485 | 0.66 | RET (0.35) | NOS2 | |
| SCHEMBL27836774 | 0.66 | NOS2 (0.41) | ADORA2AADORA2BNOS2 | |
| SCHEMBL19700415 | 0.64 | CA12 (0.34) | — | |
| SCHEMBL9974272 | 0.64 | MPO (0.32) | ADORA2AADORA2BNOS3NOS2 | |
| SCHEMBL691266 | 0.64 | ABL1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421537-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010062578-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-06-03 | — | — | WO | disclosed |