Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6918652 | 0.89 | MDM2 (0.41) | MDM2 | |
| SCHEMBL6917695 | 0.86 | MGLL (0.35) | DPEP1 | |
| SCHEMBL2316531 | 0.86 | KMT2A (0.35) | MDM2 | |
| SCHEMBL6917109 | 0.86 | MGLL (0.35) | DPEP1 | |
| SCHEMBL6917599 | 0.81 | DGAT1 (0.40) | — | |
| SCHEMBL2318758 | 0.81 | MDM2 (0.47) | MDM2EPHX2 | |
| SCHEMBL2317340 | 0.81 | MDM2 (0.35) | MDM2 | |
| SCHEMBL6918702 | 0.79 | FFAR1 (0.40) | EPHX2 | |
| SCHEMBL6917699 | 0.78 | PSEN1 (0.40) | — | |
| SCHEMBL13836534 | 0.75 | MDM2 (0.38) | MDM2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011092611-A1 | AMINOCYCLOHEXANES AND AMINOTETRAHYDROPYRANS AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2011-08-04 | — | — | WO | disclosed |