SCHEMBL691760

SCHEMBL691760

CCc1nc2c(C)nc(C)cc2n1-c1ccc(CCOC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 1/20 0.75
KMT2A Q03164 4/20 0.43
TP53 P04637 2/20 0.43
AGTR1 P30556 7/20 0.41
AGTR2 P50052 6/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 2/20 0.39
GMNN O75496 1/20 0.38
USP2 O75604 1/20 0.38
LMNA P02545 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C9 P11712 1/20 0.38
TSHR P16473 1/20 0.38
NFKB1 P19838 1/20 0.38
APEX1 P27695 1/20 0.38
CYP2C19 P33261 1/20 0.38
THPO P40225 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30114805 1.00 PTGER4 (0.75) PTGER4KMT2ATP53AGTR1AGTR2
SCHEMBL691805 0.93 PTGER4 (0.66) PTGER4KMT2ATP53AGTR1AGTR2
SCHEMBL30114954 0.93 PTGER4 (0.66) PTGER4KMT2ATP53AGTR1AGTR2
SCHEMBL21470064 0.90 PTGER4 (0.62) PTGER4KMT2ATP53AGTR1AGTR2
SCHEMBL30114861 0.90 PTGER4 (0.62) PTGER4KMT2ATP53AGTR1AGTR2
SCHEMBL30114829 0.88 PTGER4 (0.59) PTGER4KMT2ATP53AGTR1AGTR2
SCHEMBL691506 0.88 PTGER4 (0.59) PTGER4KMT2ATP53AGTR1AGTR2
SCHEMBL21470224 0.87 PTGER4 (0.58) PTGER4KMT2ATP53AGTR1AGTR2
SCHEMBL30114997 0.87 PTGER4 (0.58) PTGER4KMT2ATP53AGTR1AGTR2
SCHEMBL23876637 0.86 PTGER4 (0.75) PTGER4KMT2ATP53KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170253595-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER ASKAT INC. (JP) 2017-09-07 US claimed
US-20160317514-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC. (JP) 2016-11-03 US claimed
EP-2976105-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE AskAt Inc. (JP) 2016-01-27 EP claimed
WO-2014148053-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC. (JP) 2014-09-25 WO claimed
EP-2538978-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RaQualia Pharma Inc (JP) 2013-01-02 EP claimed
US-20120316197-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RAQUALIA PHARMA INC. (JP) 2012-12-13 US claimed
US-20120088723-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER RAQUALIA PHARMA INC. (JP) 2012-04-12 US claimed
EP-2422779-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER RaQualia Pharma Inc (JP) 2012-02-29 EP claimed
WO-2011102149-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RAQUALIA PHARMA INC. (JP) 2011-08-25 WO claimed
US-20240066040-A1 EP4 INHIBITORS AND USE THEREOF ARRYS THERAPEUTICS INC (US) 2024-02-29 US disclosed
US-20240066040-A1 EP4 INHIBITORS AND USE THEREOF ARRYS THERAPEUTICS INC (US) 2024-02-29 US disclosed
US-11840530-B2 Selective EP4 receptor antagonistic substance for treatment of cancer ASKAT INC. (JP) 2023-12-12 US disclosed
EP-2976105-B1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE ASKAT INC (JP) 2023-01-04 EP disclosed
US-20210290641-A1 EP4 INHIBITORS AND USE THEREOF ASKAT INC. (JP) 2021-09-23 US disclosed
US-20120316197-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RAQUALIA PHARMA INC. (JP) 2012-12-13 US disclosed
US-20120088723-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER RAQUALIA PHARMA INC. (JP) 2012-04-12 US disclosed
EP-2422779-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER RaQualia Pharma Inc (JP) 2012-02-29 EP disclosed
WO-2011102149-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES RAQUALIA PHARMA INC. (JP) 2011-08-25 WO disclosed
US-6710054-B2 CONTAINING SULFONYLAMINOCARBONYL GROUPS; PROSTAGLANDIN INHIBITORS PFIZER INC 2004-03-23 US disclosed
US-20020107273-A1 Aryl or heteroaryl fused imidazole compounds as anti-inflammatory and analgesic agents ASKAT INC. (JP) 2002-08-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210290641-A1 EP4 INHIBITORS AND USE THEREOF PTGER4, EPB41, PTGER1 PTGER4 1/4885KMT2A 1165/4885TP53 176/4885
US-20120316197-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF IL-23 MEDIATED DISEASES PTGER4, PTGER3, IL23R PTGER4 1/4885KMT2A 2994/4885TP53 4343/4885
US-20170253595-A1 SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER PTGER4, PTGER1, PTGER2 PTGER4 1/4885KMT2A 2765/4885TP53 1113/4885
US-20020107273-A1 Aryl or heteroaryl fused imidazole compounds as anti-inflammatory and analgesic agents PTGS1, PTGS2, OPRM1 PTGER4 51/4885KMT2A 2917/4885TP53 4389/4885
US-11840530-B2 Selective EP4 receptor antagonistic substance for treatment of cancer PTGER4, PTGER1, PTGER2 PTGER4 1/4885KMT2A 2658/4885TP53 1110/4885
US-20120088723-A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER PTGER4, PTGER1, PTGER2 PTGER4 1/4885KMT2A 2492/4885TP53 1229/4885
US-20160317514-A1 USE OF EP4 RECEPTOR ANTAGONISTS IN THE TREATMENT OF CARTILAGE DISEASE PTGER4, PTGER1, PTGER3 PTGER4 1/4885KMT2A 3121/4885TP53 3880/4885
US-20240066040-A1 EP4 INHIBITORS AND USE THEREOF PTGER4, EPB41, PTGER1 PTGER4 1/4885KMT2A 1165/4885TP53 176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.