Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.38 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | FPR1 | P21462 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13836605 | 0.87 | DGAT1 (0.50) | HRH3DGAT1KCNH2KDM1APSEN1 | |
| SCHEMBL6918804 | 0.83 | KDM4E (0.45) | KCNH2KDM1APSEN1PSEN2APH1B | |
| SCHEMBL6918303 | 0.79 | KDM1A (0.47) | KDM1A | |
| SCHEMBL6917416 | 0.77 | MDM2 (0.48) | — | |
| SCHEMBL15314513 | 0.74 | HRH3 (0.55) | HRH3DGAT1KCNH2KDM1AP2RX7 | |
| SCHEMBL12128172 | 0.74 | HRH3 (0.55) | HRH3DGAT1KCNH2KDM1AP2RX7 | |
| SCHEMBL455274 | 0.74 | HRH3 (0.55) | HRH3DGAT1KCNH2KDM1AP2RX7 | |
| SCHEMBL451266 | 0.74 | HRH3 (0.55) | HRH3DGAT1KCNH2KDM1AP2RX7 | |
| SCHEMBL180703 | 0.70 | DGAT1 (0.81) | DGAT1FPR1FPR2 | |
| SCHEMBL23550031 | 0.70 | HRH3 (0.58) | HRH3DGAT1KCNH2KDM1ASSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120295923-A1 | Aminocyclohexanes and Aminotetrahydropyrans and Related Compounds As Gamma-Secretase Modulators | PFIZER INC. | 2012-11-22 | — | — | US | disclosed |
| WO-2011092611-A1 | AMINOCYCLOHEXANES AND AMINOTETRAHYDROPYRANS AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2011-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295923-A1 | Aminocyclohexanes and Aminotetrahydropyrans and Related Compounds As Gamma-Secretase Modulators | BACE1, BACE2, PSEN1 | HRH3 1661/4885DGAT1 3607/4885KCNH2 2392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.