SCHEMBL6918564

SCHEMBL6918564

Cn1c(C(=O)Nc2ccc(Cl)cc2-c2noc(=O)[nH]2)cc2cccc(OC3CCC3)c21.Cn1c(C(=O)Nc2ccc(Cl)cc2-c2noc(=O)[nH]2)cc2cccc(OC[C@H](O)CO)c21

nearest known ligand 0.34

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 3/20 0.34
IRAK4 Q9NWZ3 3/20 0.34
CMKLR1 Q99788 6/20 0.33
GRIK1 P39086 1/20 0.33
MDM2 Q00987 3/20 0.33
F11 P03951 1/20 0.32
KLKB1 P03952 1/20 0.32
JAK2 O60674 1/20 0.32
JAK1 P23458 1/20 0.32
TYK2 P29597 1/20 0.32
JAK3 P52333 1/20 0.32
PPARG P37231 1/20 0.31
CHRM3 P20309 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6708708 0.93 IRAK4 (0.38) IRAK4CMKLR1GRIK1MDM2F11
SCHEMBL6708711 0.93 IRAK4 (0.38) IRAK4CMKLR1GRIK1MDM2F11
SCHEMBL6708778 0.91 GRIK1 (0.39) KDM1AIRAK4CMKLR1GRIK1MDM2
SCHEMBL6913240 0.91 ALK (0.37) KDM1A
SCHEMBL6708862 0.85 GRIK1 (0.36) CMKLR1GRIK1F11KLKB1PPARG
SCHEMBL6710047 0.85 GRIK1 (0.37) KDM1ACMKLR1GRIK1MDM2PPARG
SCHEMBL6710035 0.85 GRIK1 (0.36) IRAK4GRIK1PPARG
SCHEMBL6710032 0.85 GRIK1 (0.36) IRAK4GRIK1PPARG
SCHEMBL6713869 0.84 GRIK1 (0.38) KDM1ACMKLR1GRIK1MDM2PPARG
SCHEMBL6708861 0.83 XDH (0.39) KDM1ACMKLR1GRIK1MDM2PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004018461-A2 ANTIBACTERIAL BENZOIC ACID DERIVATIVES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO disclosed