Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.36 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | RXRB | P28702 | 2/20 | 0.34 |
| ▸ | RXRG | P48443 | 2/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778519 | 0.84 | HCAR3 (0.46) | HCAR3NAPRTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1117875 | 0.79 | HCAR3 (0.48) | HCAR3NAPRTALDH1A1MEN1KMT2A | |
| SCHEMBL692389 | 0.79 | HCAR3 (0.38) | HCAR3NAPRTALDH1A1POLBPKM | |
| SCHEMBL4547078 | 0.78 | HCAR3 (0.56) | HCAR3NAPRTALDH1A1P4HTMP4HA1 | |
| SCHEMBL477388 | 0.75 | HCAR3 (0.38) | HCAR3KDM4EALDH1A1HSD17B10ALOX15 | |
| SCHEMBL15173773 | 0.75 | HCAR3 (0.38) | HCAR3KDM4EMEN1KMT2ACXCR1 | |
| SCHEMBL2099047 | 0.75 | GBA1 (0.50) | HCAR3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4596038 | 0.74 | HCAR3 (0.59) | HCAR3NAPRTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL3463002 | 0.72 | USP30 (0.53) | KDM4EALDH1A1MEN1KMT2AUSP30 | |
| SCHEMBL19899449 | 0.72 | ALDH1A1 (0.43) | KDM4EALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421872-A1 | THIA-TRIAZA-AS-INDACENES AS PI3-KINASES INHIBITORS FOR THE TREATMENT OF CANCER | Boehringer Ingelheim International GmbH (DE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010122091-A1 | THIA-TRIAZA-AS-INDACENES AS PI3-KINASES INHIBITORS FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-10-28 | — | — | WO | disclosed |