Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 5/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | MC3R | P41968 | 1/20 | 0.32 |
| ▸ | MC1R | Q01726 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6918586 | 0.88 | MASP2 (0.40) | F2GPBAR1F10PLATPRSS1 | |
| SCHEMBL6919199 | 0.87 | F2 (0.39) | F2GPBAR1KMT2AMEN1AAK1 | |
| SCHEMBL6919210 | 0.87 | F2 (0.39) | F2GPBAR1KMT2AMEN1AAK1 | |
| SCHEMBL6918796 | 0.81 | F2 (0.48) | F2F10PLATPRSS1PRSS3 | |
| SCHEMBL6918799 | 0.81 | F2 (0.48) | F2F10PLATPRSS1PRSS3 | |
| SCHEMBL6919761 | 0.79 | F2 (0.40) | F2GPBAR1KMT2AMEN1AAK1 | |
| SCHEMBL6919923 | 0.77 | F2 (0.39) | F2GPBAR1KMT2AMEN1AAK1 | |
| SCHEMBL6919166 | 0.77 | CYP3A4 (0.41) | F2GPBAR1F10PLATPRSS1 | |
| SCHEMBL6921204 | 0.75 | F2 (0.40) | F2GPBAR1KMT2AMEN1AAK1 | |
| SCHEMBL6077624 | 0.74 | F2 (0.47) | F2GPBAR1F10PLATPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004032834-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2004-04-22 | — | — | WO | claimed |
| WO-2004032834-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2004-04-22 | — | — | WO | disclosed |