Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | F9 | P00740 | 2/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16300440 | 0.88 | F9 (0.36) | AAK1F9F11F7GPR119 | |
| SCHEMBL6918457 | 0.77 | F9 (0.41) | AAK1F9F11F7EGFR | |
| SCHEMBL6920163 | 0.69 | F9 (0.43) | F9F11F7EGFRKDR | |
| SCHEMBL30386539 | 0.68 | PRMT5 (0.47) | AAK1NSD2PRMT5WDR77 | |
| SCHEMBL9608997 | 0.67 | TBK1 (0.45) | TBK1 | |
| SCHEMBL8513739 | 0.67 | F9 (0.44) | F9F11F7EGFRSRC | |
| SCHEMBL8509791 | 0.67 | ROCK2 (0.44) | F9F11F7SLC34A1TBK1 | |
| SCHEMBL1232774 | 0.66 | F9 (0.53) | F9F11F7SLC34A1 | |
| SCHEMBL17674434 | 0.66 | IDO1 (0.48) | AAK1NSD2PRMT5WDR77 | |
| SCHEMBL2871701 | 0.66 | NSD2 (0.44) | AAK1NSD2PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011017296-A1 | 4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2011-02-10 | — | — | WO | disclosed |