⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4380292 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL690424 | 0.77 | LMNA (0.34) | — | |
| SCHEMBL3114383 | 0.76 | KDM4E (0.42) | — | |
| SCHEMBL23538248 | 0.75 | NPSR1 (0.46) | — | |
| Ethylamine SCHEMBL18039338 | 0.75 | KDM4E (0.42) | — | |
| SCHEMBL13485367 | 0.74 | — | — | |
| SCHEMBL3335220 | 0.74 | — | — | |
| SCHEMBL9750585 | 0.74 | — | — | |
| SCHEMBL845581 | 0.74 | — | — | |
| SCHEMBL9627221 | 0.72 | KDM4E (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250282785-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2025-09-11 | — | — | US | disclosed |
| EP-4522608-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN Pharmaceutica NV (BE) | 2025-03-19 | — | — | EP | disclosed |
| CN-119546602-A | Pyrrolidone derivatives as inhibitors of nfkb-induced kinase | 詹森药业有限公司 | 2025-02-28 | — | — | CN | disclosed |
| WO-2023217906-A1 | PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-16 | — | — | WO | disclosed |
| US-8168642-B2 | Dihydropyrimidine compounds and their uses in preparation of medicaments for treating and preventing antiviral diseases | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2012-05-01 | — | — | US | disclosed |
| EP-2039686-B1 | DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN PREPARATION OF MEDICAMENTS FOR TREATING AND PREVENTING ANTIVIRAL DISEASES | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO LTD (CN) | 2012-02-29 | — | — | EP | disclosed |
| CN-101104617-B | Dihydropyrimidine compounds and use of the same in preparing medicament for curing and preventing virosis | BEIJING MOLIK SCIENCE & TECHNOLOGY CO LTD | 2010-06-23 | — | — | CN | disclosed |
| US-20100087448-A1 | Dihydropyrimidine Compounds and Their Uses in Preparation of Medicaments for Treating and Preventing Antiviral Diseases | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2010-04-08 | — | — | US | disclosed |
| EP-2039686-A1 | DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN PREPARATION OF MEDICAMENTS FOR TREATING AND PREVENTING ANTIVIRAL DISEASES | Beijing Molecule Science and Technology Co., Ltd. (CN) | 2009-03-25 | — | — | EP | disclosed |
| CN-101104617-A | Dihydropyrimidine compounds and use for the same in preparing medicament for curing and preventing virosis | BEIJING MOLIK SCIENCE & TECHNO (CN) | 2008-01-16 | — | — | CN | disclosed |